نتایج جستجو برای: shortening mechanism

تعداد نتایج: 582646  

2013
Allen A. Ciuffo Lisa Levin

Eight open chest dogs underwent 25 min of coronary occlusion to determine whether brief myocardial ischemia disrupts the normal myocardial inotropic response to sympathetic nervous stimulation. If so, this could represent a mechanism contributing to postischemic myocardial dysfunction. Myocardial segment shortening was measured using ultrasonic dimension crystals before and after coronary arter...

Journal: :The Journal of clinical investigation 1985
A A Ciuffo P Ouyang L C Becker L Levin M L Weisfeldt

Eight open chest dogs underwent 25 min of coronary occlusion to determine whether brief myocardial ischemia disrupts the normal myocardial inotropic response to sympathetic nervous stimulation. If so, this could represent a mechanism contributing to postischemic myocardial dysfunction. Myocardial segment shortening was measured using ultrasonic dimension crystals before and after coronary arter...

2005
ERNESTO BAN-HAYASHI

We examined the influence of left ventricular end-diastolic pressure (LVEDP) on the mechanical interaction between ischemic and nonischemic areas during acute myocardial ischemia. Circumferentially oriented ultrasonic segment gauges were implanted in the midwall of the anterior apex and posterior apex of the left ventricle in seven anesthetized dogs. Stroke volume was measured with a flow probe...

Journal: :Cardiovascular research 1998
C Holubarsch J Lüdemann S Wiessner T Ruf H Schulte-Baukloh S Schmidt-Schweda B Pieske H Posival H Just

BACKGROUND For reasons of simplicity, studies on isolated human myocardium have been conducted using exclusively isometric contractions, although positive inotropic interventions may differently influence force development, extent of shortening and myocardial work performance. We investigated human left ventricular failing and non-failing preparations comparing isometric versus isotonic, i.e., ...

Journal: :American journal of physiology. Heart and circulatory physiology 2009
Jian-Bing Shen Robin Shutt Mariela Agosto Achilles Pappano Bruce T Liang

Binary cardiac transgenic (Tg) overexpression of P2X(4) receptors (P2X(4)R) improved the survival of the cardiomyopathic calsequestrin (CSQ) mice. Here we studied the mechanism of rescue using binary P2X(4)R/CSQ Tg and CSQ Tg mice as models. Cellular and intact heart properties were determined by simultaneous sarcomere shortening (SS) and Ca(2+) transients in vitro and echocardiography in vivo....

Journal: :Circulation research 1986
G H Pollack

SERENDIPITY and technology have combined forces to reveal a phenomenon of striking proportions. What may prove to be the quantum element underlying contraction was discovered by chance, following the development of a high-resolution optical diffractometer designed to follow the dynamics of shortening in isolated cardiac muscle. Records showed a most unusual feature: periods of sarcomere shorten...

Journal: :American journal of physiology. Heart and circulatory physiology 2004
Ehsan Y Davani Delbert R Dorscheid Cheng-Han Lee Cornelis van Breemen Keith R Walley

ICAM-1 mediates interaction of cardiomyocytes with the extracellular matrix and leukocytes and may play a role in altering contractility. To investigate this possibility, rat ventricular cardiomyocytes were activated using TNF-alpha, IL-1beta, or LPS, washed, cultured with quiescent rat polymorphonuclear leukocytes (PMNs) for 4 h, and electrically stimulated to determine fractional shortening. ...

Journal: :Circulation 1985
W Y Lew E Ban-Hayashi

We examined the influence of left ventricular end-diastolic pressure (LVEDP) on the mechanical interaction between ischemic and nonischemic areas during acute myocardial ischemia. Circumferentially oriented ultrasonic segment gauges were implanted in the midwall of the anterior apex and posterior apex of the left ventricle in seven anesthetized dogs. Stroke volume was measured with a flow probe...

Journal: :Circulation 2012
Kihei Yoneyama Ola Gjesdal Eui-Young Choi Colin O Wu W Gregory Hundley Antoinette S Gomes Chia-Ying Liu Robyn L McClelland David A Bluemke Joao A C Lima

BACKGROUND The aim of the present study was to evaluate how torsion is influenced by left ventricular (LV) remodeling associated with age, sex, and hypertension in a large community-based population. METHODS AND RESULTS Myocardial shortening and torsion were assessed by tagged cardiac magnetic resonance in 1478 participants without clinically apparent cardiovascular disease in the Multi-Ethni...

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