INTRODUCTION Hyponatremia secondary to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) during amiodarone therapy is a rare but potentially lethal adverse effect. We report a case of severe hyponatremia associated with amiodarone, and discuss its clinical implications. CASE REPORT An 84-year-old Caucasian man with a past medical history of hypertension and diabetes was adm...

BACKGROUND AND OBJECTIVES Vaptans (vasopressin V(2)-receptor antagonists) are a new approach for the treatment of hyponatremia. However, their indications remain to be determined, and their benefit compared with that of the usual treatments for the syndrome of inappropriate antidiuretic hormone secretion (SIADH) have not been evaluated. This prospective, long-term study compared the efficacy, t...

BACKGROUND Syphilis has increased in prevalence the United States by 72.7% from 2013 to 2017, with highest rates recorded men who have sex men. There is an incidence of syphilis patients a concomitant HIV infection, estimated at 77-fold increase. CASE REPORT This report documents unusual case neurosyphilis manifesting as syndrome inappropriate antidiuretic hormone secretion (SIADH) 56-year-old ...

はじめに SIADH(syndrome of inappropriate secretion of ADH)は 低ナ トリウム麺症を主徴とする病態 である.これを非SIADHの 低ナ トリウム血症と比 較した場合,SIADHで は水分摂取の制限が低ナ ト リウム血症 の治療上有 効であ るの に対 と,非 SIADHで は血清ナ トリウム値の正常化 に先だつ て,脱 水や虚脱等,液 きに危険を伴 う副作用を招 く点で,両 者の鑑別診断は臨床上大き な意味をも つものといえる. ,ラ ジナイム ノアッセイによる血中ADHの 測定が可能 となつて,各 種の低ナ トリウム血症に ついて血中ADH濃 度を検討すると, SIADHの み ならず非SIADHにお いて も多 くの症例 で血 中 ADH濃 度の上昇がみ とめられる.非SIADHの 低 ナ トリウム血症の発症や維持に際 とて も,血...

Hyponatremia secondary to the Syndrome of Inappropriate Anti-Diuretic Hormone (SIADH) secretion is commonly observed in patients with various neurological disorders. Cerebral Salt Wasting (CSW) resulting in hyponatremia is also an infrequent occurrence in some patients with neurological disorders. Confusion in differentiating CSW from SIADH may arise since both results in similar electrolyte di...