OBJECTIVE To assess the efficacy of Aloe Vera gel compared with 1% silver sulfadiazine cream as a burn dressing for the treatment of superficial and partial thickness burns. METHODS This Interventional Comparative study was carried out at the Burn unit and Plastic surgery department, Nishtar Hospital Multan, Pakistan from July 2008 to December 2010. A total of 50 patients with superficial and...

Clinical trials comparing different drug regimens and strategies for the treatment of congenital toxoplasmosis and its clinical manifestations in the liveborn child in different clinical settings should aim at formally evaluating the net benefit of existing treatments and at developing new therapeutic options. Currently, there is no ideal drug for congenital toxoplasmosis; future research shoul...

Influence of alloxan induced metabolic disorder on the biodisposition kinetics of a weakly acidic drug sulphadiazine was investigated in rabbits. In 12 rabbits, mean +/- SD blood pH was 7.45 +/- 0.05, plasma glucose 123 +/- 10.6 mg%, plasma total lipids 336 +/- 124 mg% and plasma urea 36 +/- 6 mg%. After treatment with 150 mg/kg alloxan intravenously the blood pH was 7.20 +/- 0.06, plasma gluco...

Departments of Pharmacology, and of Bacteriology and Pathology, School of Tropical Medicine, Calcutta Sulphadiazine has been reported to be of value in human plague by Wagle (1944). Mortality is reduced to 12 per cent whereas in cases treated with iodine, etc.; the mortality is 53 per cent. In this paper, we have shown the efficacy of the drug in experimental plague in guinea-pigs. Penicillin o...

A study was conducted to synthesise and evaluate the anti-inflammatory and anti-microbial activities of mannich bases from 1, 2 - hydroxy pyrazolines. For this, vanillin was reacted with substituted acetophenones and different vanillinyl chalcones were obtained which when coupled with phenyl hydrazine, produced hudroxy 1, 2 - pyrazolines. The hydroxyl pyrazolines were reacted with sulpha drugs ...