Replication of alphaviruses in vertebrate cells strongly affects cell physiology and ultimately leads to development of a cytopathic effect (CPE) and cell death. Sindbis virus (SIN) replication causes major changes in cellular macromolecular synthesis, in which the strong downregulation of transcription of cellular mRNAs and rRNAs plays a critical role. SIN nonstructural protein nsP2 was previo...

Speech-in-noise (SIN) perception is a complex cognitive skill that affects social, vocational, and educational activities. Poor SIN ability particularly affects young and elderly populations, yet varies considerably even among healthy young adults with normal hearing. Although SIN skills are known to be influenced by top-down processes that can selectively enhance lower-level sound representati...

In most cell types, mitosis and cytokinesis are tightly coupled such that cytokinesis occurs only once per cell cycle. The fission yeast Schizosaccharomyces pombe divides using an actomyosin-based contractile ring and is an attractive model for the study of the links between mitosis and cytokinesis. In fission yeast, the anaphase-promoting complex/cyclosome (APC/C) and the septation initiation ...

Effects of the 1-3 leptonic mixing on the solar neutrino observables are studied and the signatures of non-zero θ13 are identified. For this we have re-derived the formula for 3νsurvival probability including all relevant corrections and constructed the iso-contours of observables in the sin θ12−sin θ13 plane. Analysis of the solar neutrino data gives sin θ13 = 0.007 −0.007 (90% C.L.) for ∆m 2 ...

In this article a group-theoretical aspect of the method of dimensional reduction is presented. Then, on the base of symmetry analysis of an anisotropic space geometrical description of dimensional reduction of equations for vector massless field is given. Formula for calculating components of the energymomentum tensor from the variables of the field factor-equations is derived. The covariant e...