Dysregulated expression or activation of matrix metalloproteinases (MMPs) is observed in many kinds of live-threatening diseases. Therefore, MMP imaging for example with radiolabelled MMP inhibitors (MMPIs) potentially represents a valuable tool for clinical diagnostics using non-invasive single photon emission computed tomography (SPECT) or positron emission tomography (PET) imaging. This work...

Over the past 20 years brain Single Photon Emission Computed Tomography (SPECT) imaging has developed a substantial, evidence-based foundation and is now recommended by professional societies for numerous indications relevant to psychiatric practice. Unfortunately, SPECT in clinical practice is utilized by only a handful of clinicians. This article presents a rationale for a more widespread use...

introduction: in single photon emission computed tomography (spect), the projection data used for image reconstruction are distorted by several factors, including attenuation and scattering of gamma rays, collimator structure, data acquisition method, organ motion, and washout of radiopharmaceuticals. all these make reconstruction of a quantitative spect image very difficult. simulation of a sp...

Parkinsonian symptoms are associated with a number of neurodegenerative disorders, such as Parkinson’s disease, multiple system atrophy, and progressive supranuclear palsy. Positron emission tomography (PET) and single-photon emission tomography (SPECT) now are able to visualize and quantify changes in cerebral blood flow, glucose metabolism, and neurotransmitter function produced by parkinsoni...

In this review, first principles of positron emission tomography (PET) and single photon emission tomography (SPECT) are discussed together with the relative strengths and weaknesses of both techniques. With both modalities it is possible to image and, especially with PET, to measure regional tissue function, the particular function being interrogated depending on the actual tracer being used. ...

PURPOSE Pain related to costovertebral and costotransverse joints is likely an underrecognized and potentially important cause of thoracic back pain. On combined single-photon emission computed tomography and computed tomography (SPECT-CT), increased technetium-99m methylene diphosphonate (99mTc MDP) activity at these articulations is not uncommon. We evaluated whether this activity corresponds...

We present the clinical, laboratory, computed tomography (CT), single photon emission computed tomography (SPECT), and histopathological findings of a patient with adrenocorticotropic hormone (ACTH) dependent Cushing's syndrome with massive bilateral adrenal gland hyperplasia due to a hilar ACTH-producing well-differentiated neuroendocrine carcinoma.

Hybrid scanners, which enable the performance of single photon emission tomography (SPECT) and X-ray computerized tomography (CT) in one procedure, have considerable potential as an all-rounder in the nuclear medicine departments. However, challenges remain in validating the accuracy of such hybrid systems. In this paper, a systematic validation method with minimum user interaction is proposed,...

In the rapidly changing world of medicine, boundaries between specialties are constantly being challenged. Fused and hybrid imaging with integration of single photon emission computed tomography (SPECT) and computed tomography (CT)(SPECT/ CT) and positron emission tomography (PET) and CT (PET/CT), represent an area of very rapid growth with significant implications for the medical profession. S...

The aim of this study was to compare the accuracy of computed tomography (CT) and single photon emission computerized tomography (SPECT) in the diagnosis of dementia. Fifty-two patients with clinical diagnosis of dementia and 11 controls were studied. The scans were interpreted by one experienced neuroradiologist and one nuclear radiologist, both blinded to the clinical data. In the diagnosis o...