Chemoimmunotherapy with antibody-drug conjugates (ADC) is emerging as a promising therapy for solid tumors, whereas radioimmunotherapy (RAIT) of solid tumors has been relatively ineffective because of their resistance to radiation. We developed antibody-SN-38 conjugates that have significant antitumor activity in xenograft models at nontoxic doses. The goal of this study was to determine if an ...

BACKGROUND AND PURPOSE Accurate imaging characterization of a solitary thyroid nodule has been clearly problematic. The purpose of this study was to evaluate the role of the apparent diffusion coefficient (ADC) values in the differentiation between malignant and benign solitary thyroid nodules. MATERIALS AND METHODS A prospective study was conducted in 67 consecutive patients with solitary th...

We present an efficient implementation of the second- and third-order single-reference algebraic diagrammatic construction theory for electron attachment (EA) ionization (IP) energies spectra (EA/IP-ADC(n), n = 2, 3). Our new EA/IP-ADC program features spin adaptation closed-shell systems, density fitting handling two-electron integral tensors, as well vectorized parallel tensor contractions. d...

Background: Diffusion-weighted imaging (DWI) is one of methods in evaluation of breast lesions. We aimed to investigate the apparent diffusion coefficient (ADC) values in breast tumors and their accuracy in differentiating benign versus malignant lesions. Methods: In this cross-sectional study, 72 patients with 88 breast lesions were investigated by 1.5-T breast MRI from 2015 to 2017 in Athari...

A 12b 2MS/s cyclic ADC achieves low power consumption with a single-ended rail-to-rail input signal range of 3.3Vp-p. The proposed voltage reference scheme directly employing power supply voltages implements an offset voltage less than 1mV without well-known calibration and trimming techniques. The prototype ADC in a 0.18mm CMOS technology demonstrates the effective number of bits of 11.48 for ...

BACKGROUND Transformers are used for isolation and to convert signals from single-ended to differential. A factor often overlooked when using transformers in the front-end circuitry of high-speed A/D converters is that they are never ideal. With sinusoidal input signals, any imbalance introduced by the transformer delivers an imperfect sinusoidal wave to the input of the ADC, and results in ove...

Image Modality Specificity(%) AUC (95% CI) p value T2 70 0.85 (0.64-0.96) 0.01 DWI b500 80 0.62 (0.36-0.83) 0.52 ADC (0-500) 61.1 0.75 (0.51-0.91) 0.15 DCE subtraction 60 0.76 (0.54-0.91) 0.11 Ktrans 55 0.82 (0.61-0.95) 0.03 Kep 55 0.75 (0.52-0.90) 0.14 Ve 64.7 0.78 (0.54-0.93) 0.08 Wash out 70.5 0.86 (0.63-0.97) 0.03 Max Slope 55 0.77 (0.55-0.92) 0.10 Correlation of Histology from MR guided Tr...

Errors induced due to ratiometric measurements are discussed and a simplified compensation method to reduce the various static errors of ADC, voltage reference errors in ratiometry and resistance mismatch errors is proposed. Curve fitting is done for the error samples and the system is modelled in comparison to an ideal system. Static errors and other ratiometric errors, thus modelled are deriv...

Methods Forty patients were enrolled in a Phase I dose escalation trial to test the safety and feasibility of intratumoral injection of aDC in solid tumors. aDC were administered intratumorally under image guidance, at a dose of 2 million, 6 million, or 15 million live, activated, autologous DC per injection. At each injection visit (days 0, 7, 14, then weeks 8, 16 and 32), a single lesion was ...

This project explores the design of a type of direct-conversion ADC called a Residue Amplifier Pipeline ADC. Direct-conversion ADCs are a class of ADCs that operate at very high speeds, because the input signal is converted to a digital value in a single iteration. Other types of ADCs require many comparison iterations to convert the signal, resulting in much slower conversion times. This desig...