BackgroundAllergy, eosinophilic inflammation, and epithelial dysregulation are implicated in severe asthma pathogenesis.ObjectiveWe characterized biomarker expression adults with asthma.MethodsWithin the International Severe Asthma Registry (ISAR), we analyzed data from 10 countries North America, Europe, Asia, prespecified thresholds for positivity (serum IgE ≥ 75 kU/L, blood eosinophils 300 c...

INTRODUCTION Inverted papillomas are benign sinonasal lesions that arise primarily from the lateral nasal wall which are characterized by their tendency to recur and propensity to be associated with malignancy. The aim of this work is to analyze our experience in the treatment of these lesions, especially through the endoscopic approach. MATERIAL AND METHOD We present 61 cases of sinonasal in...

a rare case of diffuse lymphomatous polyposis of the gastrointestinal tract is reported in which the patient presented with abdominal pain, weight loss and bloody diarrhea. x-rays revealed multiple polyps involving the stomach, small intestine and colon. biopsies confirmed the diagnosis of lymphomatous polyposis. the duration of symptoms and signs was 3 months. diffuse lymphomatous polyposis of...

BACKGROUND Sinusitis is a common disease in the horse. In human medicine it is described, that obstruction of the sinonasal communication plays a major role in the development of sinusitis. To get spatial sense of the equine specific communication ways between the nasal cavity and the paranasal sinuses, heads of 19 horses, aged 2 to 26 years, were analyzed using three-dimensional (3D) reformatt...

INTRODUCTION To evaluate the most sensitive symptom to predict early recurrence of nasal polyposis. Prospective longitudinal cohort study. Tertiary university referral center with accredited otorhinolaryngology residency programs. MATERIALS AND METHODS In this prospective study, we evaluated 62 patients with diffuse nasal polyposis. All patients underwent functional endoscopic sinus surgery. ...

Nasal polyposis is characterized by persistent inflammation and remodeling in sinonasal mucosa. Toll-like receptors (TLRs) play a role in the innate immune response to microbes in the sinonasal cavity. The aim of this study was to evaluate whether nasal polyp-derived fibroblasts (NPDFs) and organ-cultured nasal polyps can synthesize pro-inflammatory cytokines and matrix metalloproteinases (MMPs...

Sinonasal papilloma is a common benign epithelial tumor of the sinonasal tract and accounts for 0.5% to 4% of all nasal tumors. The etiology of sinonasal papilloma remains unclear, although human papilloma virus has been proposed as a major risk factor. Other etiological factors, such as anatomical variations of the nasal cavity, may be related to the pathogenesis of sinonasal papilloma, becaus...

OBJECTIVE The aim of this study was to assess the relationship between clinical, radiological and histopathological findings in nasal polyposis. MATERIAL AND METHOD This was a retrospective study of 85 patients with nasal polyposis who were treated by endoscopic sinus surgery between the years of 2005 and 2010. All patients underwent preoperative paranasal sinus Computerized Tomography scan i...

Background: Olfactory neuroblastoma also known as Esthesioneuroblastoma (ENB) is a tumor arising from the basal layer of olfactory epithelium in the superior recess of the nasal cavity in the region of cribriform plate. Incidence peaks once in 11 20 years of age and again in 50 60 years of age. It is equally found in men and women. Aim: The main aim of this case report is to characterize the cl...