The aim of the investigation was research N-deacetyllappaconitine hydrochloride antiarrhythmic properties. It found that studied substance effective on cardiac arrhythmias model caused by aconitine hydrochloride, but does not act models calciume chlorideinduced and reperfusion ventricular fibrillation. compound is less toxic than comparison drug lappaconitine hydrobromide acts in lower doses ar...

The objective of this study was to determine the effect of povidone. hydroxypropyl methylcellulose, hydroxypropyl cellulose, lactose and magnesium stearate on the stability of quinapril hydrochloride. The applied HPLC method was validated by the following parameters: selectivity, precision, linearity and accuracy. Binary 1:4 mixtures of quinapril hydrochloride and selected excipients were stabl...

copper amine oxidases (caos) catalyse the oxidative de-amination of biogenic amines which are ubiquitous compounds essential for cell growth and proliferation. the enzymes are homodimers containing both topaquinone and a cu(ii) ions as cofactors at the active site of each subunit. after extraction and purification of chickpea (cicer arietinum) amine oxidase by chromatoghraphy, km and vmax of th...

Conditions for determination of: ketotifen hydrogen fumarate, azelastine hydrochloride, dimetindene maleate and promethazine hydrochloride by densitometric method in substances and pharmaceuticals were provided. Maximum wavelenghts were: 228 nm for ketotifen hydrogen fumarate, 295 nm for azelastine hydrochloride, 265 nm for dimetindene maleate and 255 nm for promethazine hydrochloride. The limi...

To identify drugs that are potentially used for the treatment of COVID-19, potency 1403 FDA-approved were evaluated using a robust pseudovirus assay and candidates further confirmed by authentic SARS-CoV-2 assay. Four compounds, Clomiphene (citrate), Vortioxetine, Vortioxetine (hydrobromide) Asenapine (hydrochloride), showed potent inhibitory effects in both virus The combination (hydrochloride...

BACKGROUND Interaction between local anesthetic solution, lidocaine hydrochloride (with and without adrenaline), and root canal irrigants such as sodium hypochlorite (NaOCl), ethylene diamine tetra-acetic acid (EDTA), and chlorhexidine (CHX) has not been studied earlier. Hence, the purpose of this in vitro study was to evaluate the chemical interaction between 2% lidocaine hydrochloride (with a...

the goal of this study was to determine the effects of ?-agonist zilpaterol hydrochloride on growth performance and carcass quality in ross broiler chicken. zilpaterol hydrochloride was daily fed at levels 0, 0.2, 0.25, 0.3 mg/kg of live body weight (lbw) from d 25 to 45 of age. eighty 308 ross female broiler chickens were employed in a 20 d feeding trial of four replicates, five birds per trea...

the aim of the present study was to develop and investigate the feasibility of delivering nebivolol as a transdermal patch by iontophoresis. the passive and electrically assisted transdermal delivery of nebivolol hydrochloride by iontophoresis will improve the therapeutic efficacy and overcome the difficulties raised in oral drug delivery. because of its extensive hepatic metabolism and low dos...

A simple and fast FI colorimetric procedure for determination of doxorubicin hydrochloride (DXH) was proposed. It is based on the redox reaction between iron (III) and DXH, resulting in an intensely red colored complex in the presence of 1, 10-orthophenantroline which can be followed by spectrophotometric measurement at λmax= 510 nm. This is an automatic way to determine doxorubicin hydrochlori...