A generalized skin eruption with strong itching was induced by sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, in a patient almost 6 months after initiation of the drug. Physical examination revealed a spread of skin rash from chest to back, and abdomen and thigh. Discontinuation of the drug eliminated the skin rash immediately. The emergence of new rash ended, and the rash itself with...

Pemphigus vulgaris (PV) is an autoimmune blistering disease affecting the skin and mucosa. It clinically presents as painful erosions, mainly in oral cavity, flaccid blisters erosions on skin. Steven-johnson syndrome/toxic epidermal necrolysis (SJS/TEN) a severe mucocutaneous drug hypersensitivity reaction characterized by painful, dusky, erythematous eruptions that often progress to blisters, ...

to inform healthcare professionals of a rare serious reaction leading to leg amputation following intramuscular injection of iron dextran and report comments for preventing such reactions.a case of leg amputation following intramuscular injection of iron dextran reported to iranian pharmacovigilance center was reviewed. patient and reaction data was collected by assessing the reported yellow ca...

Adverse cutaneous manifestations are among the most common side effects associated with psychotropic drugs. Skin reactions due to amitriptyline (a tricyclic antidepressant agent) include rashes and hypersensitivity reactions (for example, urticaria and photosensitivity) as well as hyperpigmentation. Hypersensitivity syndrome is a specific severe idiosyncratic reaction causing skin, liver, joint...

PURPOSE OF REVIEW This review presents the current knowledge of the role of T cells in drug allergy manifesting as exanthematous, pustular and bullous skin diseases, collectively referred to as nonimmediate allergic drug reactions. RECENT FINDINGS Both CD4+ and CD8+ T cells producing type 1 and type 2 cytokines and endowed with cytotoxic properties are involved in nonimmediate allergic drug r...

results: a total number of 117 patients were evaluated for adverse drug reactions, among them, 97 (82.9%) were considered to have immunological drug reactions. the most common symptoms of allergic drug reactions were morbilliform eruptions, serum sickness, dress (drug rash with eosinophilia and systemic symptoms), and toxic epidermal necrolysis. in 62 patients, anticonvulsant drugs had the prom...

Drug hypersensitivity reactions (DHR) have potential for significant morbidity and mortality, without clear treatment severe reactions. Standard of care is to immediately stop culprit drug(s) never rechallenge. However, the drug and/or whether patient would develop a form DHR unknown. Even if reaction severe, may no alternative their underlying disease. Analysis bulk transcriptional profiling s...

M.B. is a 71-year-old male who presented in January 2001 with renal cell carcinoma metastatic to paraesophageal, peri-aortic, hilar, and mediastinal lymph nodes. He was started on interleukin-2 (IL-2, aldesleukin) 18 million units, interferon alpha 10 million units, and 5-fluorouracil 1 g, all administered by IV continuous infusion for 96 hours every three weeks. No significant complications oc...

Background: Drug allergy (DA) or hypersensitivity is an immunologically mediated reaction producing stereotype symptoms which challenging for health care providers (HCP). Objective of current study was to assess the knowledge, attitudes and practices drug among healthcare in eastern India. Methods: A 25-item self-administered DA questionnaire developed applied our study. The covered 3 domains: ...

Stevens-Johnson syndrome (SJS) is an acute life-threatening mucocutaneous reaction, characterized by extensive necrosis and detachment of the epidermis from the skin. The overall incidence of SJS is seen in five cases per million people per year. SJS is typically caused by drugs and is a kind of idiosyncratic reaction. Adverse drug reactions such an SJS have a remarkable effect on patient's saf...