Replacement of the rabbit Draize skin irritation test or the animal photo-irritation test is in course in Europe under the REACH chemical strategy and the Cosmetics Directive. Various in vitro protocols, including 3D skin models, have been assessed. One key difficulty in determining the validity of alternative in vitro methods is that the in vivo animal data is both scarce and often of limited ...

This article provides the data obtained on an extract of the micro-algal Chlorella vulgaris, which was developed andnamed Dermochlorella. Some data were already known, and others were obtained after new in vitro tests ondifferent skin cells and clinical tests made on skin microcirculation, skin restructuring and skin protection againstUV irradiations. All these data conclude tha...

BACKGROUND Diagnosis of food allergy is difficult in children. Food allergies are diagnosed using several methods that include medical histories, clinical examinations, skin prick and serum-specific immunoglobulin E (IgE) tests, radio-allergosorbent test (RAST), food challenge, and supervised elimination diets. In this study we evaluated allergies to cow's milk, egg, peanut, and fish in childre...

the prevalence of food allergy is different in various nations. the identification of the most common food allergens is a priority in any population to provide effective preventive and curative measures. the aim of this study is to determine the most common food allergens in iranian children. one hundred and ninety children with skin, respiratory or gastrointestinal symptoms, which were thought...

Background: The tuberculin test is widely used to identify tuberculosis infection. Some individuals infected with Mycobacterium tuberculosis may have an initial negative skin test reaction to tuberculin. The two step purified protein derivative skin test can decrease misinterpretation of tuberculin test .This study was aimed at comparing the two- step tuberculin skin test and booster phenomenon...

Skin is an important barrier protecting the organism against external environmental factors. Determination of its mechanical characteristics as regards its structure has significant scientific and application value. In this work, uniaxial tensile tests were conducted to determine the basic mechanical parameters of skin with respect to its structure. The subject of the study were skin samples ta...

The clinical significance of the high prevalence of positive immediate skin tests in cystic fibrosis is unclear. Using analysis of variance, we have tested the hypothesis that patients with allergic cystic fibrosis have worse lung disease than non-allergic patients. Clinical data, skin prick tests, total or specific IgE antibody levels, chest radiographs, and pulmonary function tests were obtai...

conclusions here we review the clinical applications, advantages, and limitations of the tuberculin skin test and interferon-gamma release assays and provide an overview of the most recent systematic reviews conducted for the comparison of these tests. context it has been estimated that one-third of the world’s population are suffering from latent tuberculosis infection (ltbi). in order to cont...