Rheumatoid arthritis can manifest itself through synovitis, of which the knee is the common locale. The treatment using an intra-articular radioisotope injection has been applied in various countries. In this work, the dose of radioactive material absorbed in the joint is evaluated, taking into consideration the dose received in the articular cartilage and adjacencies using a three-dimensional ...

7 Andrews PJD, Piper IR, Deardon NM, et al. Secondary insults during intrahospital transport of head injured patients. Lancet 1990;335:327-30. 8 Gentleman D, Jennett B. Audit of transfer of unconscious head injured patients to a neurosurgical unit. Lancet 1990; 335:330-4. 9 Lambert SM, Willett K. Transfer of multiply injured patients for neurosurgical opinion: a study of the adequacy of assessm...

Objective: To examine the relation between longitudinal left ventricular function assessed by tissue Doppler imaging (TDi) and exercise capacity in heart failure. Subjects: 153 patients with chronic heart failure from left ventricular systolic dysfunction (ejection fraction , 45%) and 87 age and sex matched controls. Methods: Echocardiography was used to measure conventional indices of left ven...

Semisolid (methylcellulose) hemopoietic cultures revealed the presence of histamine-containing granulocyte colonies derived from precursors (CFU-C) present in human peripheral blood. Light microscopy and histochemical studies of cells in individual histamine-containing colonies demonstrated homogeneous populations of metachromatic basophil/mast cells (BMC) at various stages of maturation. By in...

OBJECTIVE We evaluated the relationship between the HO1 genotype, ferritin levels and the risk of type-2 diabetes and inflammation. RESEARCH METHODS Eight hundred thirty-five individuals were evaluated and classified according to their nutritional status and the presence of type-2 diabetes: 153 overweight (OW); 62 obese (OB); 55 type-2 diabetes mellitus (DM); 202 OWDM; 239 OBDM and 124 contro...

We identified the enzyme(s) involved in the hydrolysis of the ethyl ester prodrug CDP323 (C28H29BrN403) and characterized its transesterification in the presence of ethanol with special emphasis on the risks of drug-drug interaction. The hydrolysis of CDP323 was evaluated in vitro using human liver and intestinal microsomes and recombinant human carboxylesterases (hCES1 and 2) and was shown to ...

This study characterized the kinetics, variability, and factors that affect UDP–glucuronic acid (UDP-GlcUA) uptake by human liver microsomes (HLM). Biphasic kinetics were observed for UDP-GlcUA uptake by HLM. Uptake affinities (assessed as Kd) of the highand low-affinity components differed by more than an order of magnitude (13 6 6 vs. 374 6 175 mM), but were comparable in terms of the maximal...

Numerous plant species are considered weeds in agronomic cropping systems. Weeds have many attributes undesirable to crop producers, not the least being the ability to reduce crop yields through competition for resources such as sunlight, water, nutrients, and space. Weeds also may harbor insects and provide a host for certain plant pathogens. Some weed species, such as wild garlic and eastern ...