A goal of dietary management of cardiovascular disease risk in patients with obesity and metabolic syndrome is improvement in the atherogenic dyslipidemia comprising elevated triglyceride, reduced high-density lipoprotein (HDL) cholesterol, and increased numbers of small, dense low-density lipoprotein (LDL) particles. Individuals with a genetically influenced trait characterized by a high propo...

nonenzymatic glycation of low density lipoprotein (ldl) is a reaction of glucose and other reducing sugars with apolipoprotein b100 (apo-b100) lysine residues. in diabetes, this reaction is greatly accelerated and is important in the pathogenesis of diabetic complications. the objective of this study was to investigate in vitro effects of ?-tocopherol, ascorbic acid and lycopene on ldl glycatio...

osteonectin is a bone- associated protein involved in vascular calcification. adiponectin may protect against cardiovascular disease but possible effects on vascular calcification have been poorly studied. the aim of this study was to investigate the modulatory effect of adiponectin on oxidized low density lipoprotein (oxldl)- induced expression of osteonectin in human aorta vascular smooth mus...

During the past two decades, the importance of the quality of low-density lipoprotein (LDL) particles – in addition to its quantity – has become of increasing interest. The risk of cardiovascular events was recognized to be closely linked to a predominance of small, dense LDL particles. In addition, in patients with Type 2 diabetes mellitus, the disease itself and its severity (in particular th...

Diabetic dyslipidemia is characterised by high plasma triglycerides (TG), low highdensity lipoprotein cholesterol (HDL-C) and increased small dense low-density lipoprotein cholesterol (LDL-C) particles. Obesity, poor glycaemic control, high fat low fibre diet, and smoking increase the risk of dyslipidemia in type 2 diabetes. Recent published reports have suggested beneficial effect of nutraceut...

the worldwide prevalence of insulin resistant states such as the metabolic syndrome has grown rapidly over the past few decades. the metabolic syndrome is a constellation of common metabolic disorders that promote the development of atherosclerosis and cardiovascular disease. studies in both human and animal models suggest that hepatic inflammation and insulin resistance are key initiating fact...

introduction: of the factors leading to false negative results in mammography is breast tissue density, and by increasing the density of breast tissue in mammography, the mammography sensitivity decreases. on the other hand, increasing the breast tissue density leads to increased risk of breast cancer. various factors such as inheritance, genetics, hormonal and reproductive factors, and nutriti...

OBJECTIVE Recently, we established a simple method for the quantification of small dense LDL cholesterol (C) using heparin-magnesium precipitation. The small dense LDL-C level was identical to cholesterol in the denser LDL fraction with a density of 1.044 to 1.063 g/mL. The aim of this study was to examine clinical significance of this precipitation method for small dense LDL-C. METHODS AND R...