Journal:
:medical journal of islamic republic of iran
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manouchehr messripour• the department of biochemistry, faculty of pharmacy, isfahan university of medical sciences, isfahan, islamic republic of iran.
ali rastegar from the centre de neurochime du c.n.r.s., 5 rue blaise pascal, 67084 strasbourg cedex, france
lucien ciesielski from the centre de neurochime du c.n.r.s., 5 rue blaise pascal, 67084 strasbourg cedex, france
magali chabert from the centre de neurochime du c.n.r.s., 5 rue blaise pascal, 67084 strasbourg cedex, france
denis weltin from the centre de neurochime du c.n.r.s., 5 rue blaise pascal, 67084 strasbourg cedex, france
paul mandel from the centre de neurochime du c.n.r.s., 5 rue blaise pascal, 67084 strasbourg cedex, france
neuronal and astroglial cells were prepared from whole brain of three month and 30-month- old rats for study of alterations in the nuclear poly adp-ribosylation and dna breaks with age. the relative purity of the cell preparations was confirmed by the determination of the neurofilament (low molecular weight) and glutamine synthetase content of the cells using elisa. an increase (75%) in the pol...