Objective: To prepare pulmonary surfactant-superoxide dismutase (PS-SOD) Liposomes and analyze the biological characteristics of them. Methods: To prepare PS-SOD Liposomes with rotary evaporation method and analyze the formulation and bioactivity of them, including shape, size, encapsulating ratio, antioxidant activity and surface tension. Results: The PS-SOD Liposome is a kind of ivory white s...

BACKGROUND The limiting effect of ischemic preconditioning on infarct size has been reported in canine hearts, which contain considerable amounts of xanthine oxidase, a free radical-producing enzyme. Furthermore, a recent study suggested that free radicals generated during preconditioning may contribute to the cardioprotective effect of preconditioning. The present study examined 1) whether pre...

Breast cancer is the first of the most common ten cancers in Iraq. Its etiology is mulifactorial, oxidative stress and lipid peroxidation being suggested to play important roles in carcinogenesis. The purpose of this study was to investigate the oxidant-antioxidant status in breast cancer patients, by measuring SOD isoenzyme activities (total SOD, CuZn-SOD, Mn-SOD and EC-SOD) in plasma and brea...

Background and aims: The role of sphincter of Oddi dysfunction (SOD) and sphincter of Oddi manometry (SOM) in patients with post-cholecystectomy pain and idiopathic recurrent acute pancreatitis (IRAP) is controversial. We sought to survey the American Gastroenterology community to define current approaches. Methods: An electronic survey was sent to U.S. members of the American Society of Gastro...

The extent of root, rhizome, and/or stolon growth determines turfgrass sod maturity. In 1998, at Michigan State University, the Calrochan Sod Puller (CSP) was developed to measure the force necessary to tear a piece of sod. The CSP uses a battery powered hydraulic pulley to provide a consistent pulling force, and is attached to a load cell. In August 1999, sod strength measurements of different...

To investigate the possible role of the superoxide radical and its scavenging system in the human corpus luteum, superoxide dismutase (SOD) values and lipid peroxide concentrations were analysed in the corpora lutea during the menstrual cycle and in early pregnancy. Copper-zinc SOD (Cu,Zn-SOD) activities increased from the early to mid-luteal phase, and gradually decreased thereafter and were t...

Human extracellular superoxide dismutase (EC-SOD; EC 1.15.1.1) is a scavenger of superoxide anions in the extracellular space. The amino acid sequence is homologous to the intracellular counterpart, Cu/Zn superoxide dismutase (Cu/Zn-SOD), apart from N- and C-terminal extensions. Cu/Zn-SOD is a homodimer containing four cysteine residues within each subunit, and EC-SOD is a tetramer composed of ...

BACKGROUND AND PURPOSE Free radicals including superoxide are responsible for postlesional cytotoxicity. In contrast to the constitutive CuZn-superoxide dismutases (SODs), manganese-superoxide dismutase (Mn-SOD) is inducible and has the potential to protect neurons by its superoxide dismutating activity. Therefore, we studied the presence and the regional changes in Mn-SOD within the brain afte...

to 28 mM glucose. Concomitantly the SOD-specific activity (units of enzyme activity per milligram immunoreactive SOD) decreased 50% in alloxan-exposed islets. When islets were protected from alloxan toxicity by including 28 mM glucose with alloxan, the insulin secretory response and SOD specific activity remained identical to controls. Thus, SOD specific activity correlates with maintenance of ...

The superoxide free radical (O(2)(•-)) has been viewed as a likely major contributor to aging. If this is correct, then superoxide dismutase (SOD), which removes O(2)(•-), should contribute to longevity assurance. In Caenorhabditis elegans, overexpression (OE) of the major cytosolic Cu/Zn-SOD, sod-1, increases life span. But is this increase caused by enhanced antioxidant defense? sod-1 OE did ...