To determine whether mineralocorticosteroids and glucocorticosteroids have specific effects on colonic electrolyte transport, we compared the effect of aldosterone and RU 28362, a glucocorticoid receptor-specific agonist that does not bind to the aldosterone receptor, on unidirectional Na, Cl, and K fluxes across isolated mucosa of the rat distal colon. Continuous infusion of aldosterone for 7 ...

The present investigation deals with the formulation of taste masked fast disintegrating tablets of Ciprofloxacin that disintegrate in the oral cavity upon contact with saliva and thereby improve therapeutic efficacy. Ciprofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class. It is a second-generation fluoroquinolone antibacterial that kills bacteria by interfer...

In this work, the dissolution-absorption studies were conducted on marketed tablets of acyclovir (ACIVIR-200mg) and the mucoadhesive tablets of acyclovir using varying concentration of sodium lauryl sulfate as a permeation enhancer. The purpose of this study was to improve the absorption of acyclovir using sodium lauryl sulfate as permeation enhancer. The everted and perfused intestine model wa...

High water absorption of recycled brick aggregate (RBA) is one of the most discussed parameters in terms of its application in the production of concrete-its influence on the amount of mixing water and, hence, the quality of the concrete, is usually considered negative. In this paper, different methods of decreasing the absorption of RBA and, consequently, the impact on the properties of concre...

Objective: Soil salinity is one of the major worldwide environmental constraints affecting agricultural production in arid and semiarid regions. Lack of proper management of water and soil resources lead to increase soil salinity and reduce soil fertility. On the other hand, it seems simple and cheap method of measuring soil salinity is necessary. The aim of this study was to determine the rela...

A perfusion technique with a proximal occluding balloon has been used to study the absorption of glucose, sodium, and water from the human jejunum at different rates of flow. The absorption of glucose and water was significantly higher with the balloon deflated than inflated, probably because of reflux of infused solution above the point of infusion. Above the inflated balloon 0 to 4.2 ml/min o...

The effect of a new complex oligosaccharide exhibiting potent inhibitory action on alpha-glucoside hydrolases on intestinal absorption of sucrose in man was tested by constant in vivo perfusion of the jejunum. At concentrations of 4.65 or 15.5 X 10(-6)M the alpha-glucosidehydrolase inhibitor (alpha-GHI) markedly inhibited absorption of glucose from sucrose and absorption of sodium and water. Or...

The cause or causes of hypercalcemia and hypercalcuria in sarcoidosis are obscure. Harrell and Fisher (1) were the first to emphasize that hypercalcemia, hyperproteinemia and elevated serum alkaline phosphatase could occur in this disease. Dent etat (2) believed that bone destruction represented the cause of hypercalcemia. Anderson et at (3) concluded from their studies that increased calcium a...

Studies in intact animals have shown that intestinal solute absorption is enhanced with increasing flow rates; the mechanism of this phenomenon has not been explored in detail. We used single pass perfusions of rat ileum to study the effect of higher flow rate on electrolyte absorption. Augmenting perfusion rate from 0.5 to 5.0 ml/min resulted in increased rates of sodium (11.0 +/- 0.9 vs. 23.5...