We report the rational design of a chitosan-based drug delivery system. The chitosan derivative N-[(2-hydroxy-3-trimethylammonium)propyl]chitosan chloride (HTCC) was ionically cross-linked by sodium tripolyphosphate (TPP) to form sub-200-nm microgels that are responsive to pH changes. When these microgels were loaded with methotrexate disodium (MTX), a cytotoxic drug for cancer treatment, and c...

Because the use of phosphates has being recently diminished in meat industry due to the nutritional drawbacks of phosphates, some researchers started to evaluate sodium bicarbonate as phosphate replacer in meat products. The aim of this study was to evaluate the effect of different temperature combinations of dry air-cooking treatments (Air and Core temperatures: 160 76, 160 80, 200 76 and 200 ̊...

HDB disease is caused by Xanthomonas oryzae pv.oryzae, an important in rice plants. Recently, many organic compounds based antibacterial agents like chitosan are being developed. The potential raw materials for producing Black Soldier Fly (BSF) exuviae. At the development, was formulated with other ingredients such as kipahit leaves (Tithonia diversifolia) extract. This study aimed to synthesiz...

Background: The ethanolic extract of Anredera cordifolia (AC) leaves has previously been investigated to have antibacterial activity against Propionibacterium acnes. An active compound propionibacterium acnes was flavonoid. Objective: This study aimed compare antimicrobial differences between nanoparticles and alone. Method: AC were extracted then formulated into using chitosan as the polymer s...

The objective of this study was the preparation ionically crosslinked 6-mercaptopurine (6-MP) monohydrate microparticles through preparing polyelectrolyte complexes drug and polymers. Polymers such as chitosan, casein, carrageenan were used to prepare microparticles, sodium tripolyphosphate crosslinker. Microparticles characterized for their flow behavior, compressibility, percentage yield, mic...

В работе методом ионотропного гелеобразования синтезированы стабильные наночастицы хитозана. Изучены свойства образца хитозана - определены его степень дезацетилирования (83,7%), а также относительная и характеристическая вязкости растворов. Определены размеры наночастиц дзета-потенциал динамического рассеяния света. Проведено исследование влияния соотношений реагентов триполифосфата натрия на ...