1Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico, No. 155, 00196 Rome, Italy 2Department of Biology, College of Science and Technology, Temple University, 1900 N. 12th Street, Philadelphia, PA 19122, USA 3Cornea and Ocular Surface Unit, San Raffaele Hospital, Via Olgettina, No. 60, 20132 Milan, Italy 4Queen Alexandra Hospital, Southwick Hill Road, Cosham PO6 3LY, ...

The genetic analysis of development has revealed the importance of small sets of interacting genes in most morphogenetic processes. The results of gene interactions have so far been examined intuitively. This approach is largely sufficient when one deals with simple interactions, a feedback circuit for example. As more components become involved, however, it is difficult to make sure that the i...

BACKGROUND Tenascins are large glycoproteins found in the extracellular matrix of many embryonic and adult tissues. Tenascin-C is a well-studied biomarker known for its high overexpression in the stroma of most solid cancers. Tenascin-W, the least studied member of the family, is highly expressed in the stroma of colon and breast tumors and in gliomas, but not in the corresponding normal tissue...

With the development of science and technology, there are constantly new technologies used in medicine, related medical have also been greatly improved. Anatomy is one them. This technology has widely clinical practice, but traditional anatomy evaluated before surgery. There shortcomings, it impossible to a more accurate understanding disease. Therefore, improper operation may still cause some ...

Apo2L/TRAIL [Apo2 ligand/tumor necrosis factor (TNF)-related apoptosis-inducing ligand], a member of the TNF cytokine superfamily, induces cell death by apoptosis in a number of human cancer cells and is a potential agent for cancer therapy. We have characterized the in vitro stability of Apo2L/TRAIL in human serum and the tissue distribution and metabolism of Apo2L/TRAIL in a xenograft model o...

Tissue chimerism was recently described in transplanted organs from female donors into male recipients, by demonstration of the Y-chromosome in tissue-derived cells. It was claimed that these Y-chromosome positive cells were recipient derived. To find out whether the chimeric cells, derived from pregnancies of sons or blood transfusions, could have been present in the solid organs before transp...

At present, the largest group of radiopaque contrast agents (RCA) is represented by iodinecontaining RCA. However, the development of abdominal interventional X-ray surgery places stringent requirements upon RCA. High contrast must be combined with pharmacological and physiological inertness, low toxicity, with the ability to be uniformly adsorbed as a thin layer on the surface of mucous organs...

PURPOSE Organ segmentation is an essential step in the development of computer-aided diagnosis/surgery systems based on computed tomography (CT) images. A universal segmentation approach/scheme that can adapt to different organ segmentations can substantially increase the efficiency and robustness of such computer-aided systems. However, this is a very challenging problem. An initial determinat...