In the present investigation, mixed-solvency approach has been applied for the enhancement of aqueous solubility of a poorly water- soluble drug, zaltoprofen (selected as a model drug), by making blends (keeping total concentrations 40% w/v, constant) of selected water-soluble substances from among the hydrotropes (urea, sodium benzoate, sodium citrate, nicotinamide); water-soluble solids (PEG-...

date syrup powder is a new product which can be used as sugar substitute. first, the date syrupwas spread out on a foil and placed in the oven at 60°c for 24 hours. date syrup was separated from the foil andgrinded. 2% agar and 2% starch were added and syrup with agar and starch that was in a lumpy shape werecrushed and spread on the foil and placed at 60°c for 24 hours. powdered granules, agar...

on experiment was designed for evaluating the nutritienal characteristics and physico-chemical properties of steam treated sugarcane pith (19 bar, 3 min.) and some other roughages. steam treatment resulted in a significant decreased (p<0.05) in ndf (77 vs. 55%), hemicellulose to cellulose ratio (0.54 vs. 0.10) and increased hemicellulose solubility of and soluble sugar fraction (20 vs. 124 mg/g...

Coconut milk has a higher water content than other contents, so microbes can easily damage and spoil it. To obtain low-moisture powder product, the liquid coconut was dried using Buchi Mini Spray dryer B-290 with inlet temperatures of 150°C, 160°C, 170°C. The researchers added maltodextrin to milk, which had ratio grated 1:3, in concentrations 9%, 10%, 11%, 12%, 13%. addition use drying tempera...

Low solubility compounds show dissolution rate limited absorption and hence poor absorption, distribution and target organ delivery. Improvement of aqueous solubility in such a case is valuable goal to improve therapeutic efficacy. Complexation with CDs by different methods like physical mixing, melting, kneding, spray drying, freeze drying, co-evaporation has been reported to enhance the solub...

In 1937, Logan and Taylor (1) came to the conclusion “that the bone salts cannot precipitate spontaneously from the bone plasma unless the ion product is increased. Once formed, the bone salts cannot dissolve unless the concentrations of the ions composing them are decreased below the concentrations found in the blood plasma.” This conclusion was based upon some observations which seemed to Log...

In 1937, Logan and Taylor (1) came to the conclusion “that the bone salts cannot precipitate spontaneously from the bone plasma unless the ion product is increased. Once formed, the bone salts cannot dissolve unless the concentrations of the ions composing them are decreased below the concentrations found in the blood plasma.” This conclusion was based upon some observations which seemed to Log...

In 1937, Logan and Taylor (1) came to the conclusion “that the bone salts cannot precipitate spontaneously from the bone plasma unless the ion product is increased. Once formed, the bone salts cannot dissolve unless the concentrations of the ions composing them are decreased below the concentrations found in the blood plasma.” This conclusion was based upon some observations which seemed to Log...

Purpose: Lovastatin is poorly water soluble drug. It should be come into the BCS II drug. So oral bioavailability of lovastatin is less (50%). To develop novel dosage foam of the self-microemulsifying drug delivery systems (SMEDDS) for the lovastatin. Methods: Before the formulation of SMEDDS, solubility study was performed in different exicipients and select exicipients on basis of solubility ...

Boronobenzo[b]quinolizinium derivatives exhibit several favorable properties for the fluorimetric detection of hydrogen peroxide, namely quantitative transformation to a product whose emission maximum is well separated from the one of the substrate, water solubility, and the ability to operate in living cells.