OBJECTIVE To investigate the frequency of pulmonary hypertension (PH) and clinical parameters associated with PH in sarcoidosis patients. METHODS A prospective, observational study was performed on 246 consecutive Japanese sarcoidosis patients followed up at the outpatient sarcoidosis clinic in the Central Clinic of Kyoto. The patients were evaluated for PH by Doppler echocardiography. Among ...

Dental caries, which affects billions of people, is a chronic infectious disease that involves Streptococcus mutans, which is nevertheless a poor predictor of individual caries development. We therefore investigated if adhesin types of S.mutans with sucrose-independent adhesion to host DMBT1 (i.e. SpaP A, B or C) and collagen (i.e. Cnm, Cbm) match and predict individual differences in caries de...

Objectives: To evaluate the associated risk factors and to determine the impact of management strategies on the outcome of PPHN. Study Design: Prospective descriptive study in tertiary center included 40 neonates having PPHN. All patients received the conventional therapy for PPHN, sildenafil as adjuvant therapy was added in cases of failure. Results: The study included 23 males, 17 females wit...

The alkaline phosphatase (AP) is a bi-metalloenzyme of potential applications in biotechnology and bioremediation, in which phosphate monoesters are nonspecifically hydrolysed under alkaline conditions to yield inorganic phosphate. The hydrolysis occurs through an enzyme intermediate in which the catalytic residue is phosphorylated. The reaction, which also requires a third metal ion, is propos...

Pulmonary hypertension (PH) resulting from left heart failure is an increasingly recognized clinical entity. To distinguish isolated postcapillary PH from combined post- and precapillary PH, the use of a diastolic pressure gradient (DPG = diastolic Pulmonary Artery Pressure - Pulmonary Arterial Wedge Pressure, dPAP - PAWP) has been advocated over the transpulmonary pressure gradient (TPG = mean...

Pulmonary arterial hypertension (PAH) is a progressive disease with high morbidity and mortality rates. Research has shown that PAH has a prevalence rate of 10-79% in thalassemia major patients. This cross-sectional study was carried out in 2014 to determine the prevalence and risk factors of PAH in all thalassemia major patients of over 18 years of age in Ilam, Iran. A cardiologist measured sy...

Pulmonary hypertension (PH) may be observed in many different conditions, including advanced heart or lung disease [1]. PH is defined as elevation of the mean pulmonary arterial pressure (mPAP) ≥25 mmHg, measured by right heart catheterization (RHC). Since procedure-related risks and costs are not negligible, RHC is not routinely performed in patients with advanced lung disease during initial a...

Abstract Background The coupling of the right ventricle (RV) to pulmonary circulation is an indicator RV performance non-invasively estimable by echocardiography. There are no data about its use in patients affected fibrotic interstitial lung diseases (f-ILD). Methods Fifty f-ILD patients, including 27 cases with idiopathic fibrosis (IPF), (M=37; mean age 67±7 yrs) were studied standard and spe...

PurposeOur prior findings demonstrated the additive value of echocardiographic parameters - specifically left ventricle end diastolic (LV ED) eccentricity index to REVEAL lite 2.0 in early prediction disease progression pulmonary arterial hypertension (PAH). The latest 2022 ESC/ERS PH guidelines suggested use Tricuspid Annular Plane Systolic Excursion Pulmonary Arterial Pressure (TAPSE/sPAP) as...