The role of glutamatergic N-methyl-D-aspartate (NMDA) receptors in memory storage processes was examined using systemic posttraining injections of MK-801. Male Long-Evans rats received an eight-trial (30-s ITI) training session on a spatial or cued water maze task. In the spatial task, a submerged escape platform was located in the same quadrant of the maze on all trials. In the cued task, a vi...

background sildenafil (viagra) has been introduced to treat erectile dysfunction by acting as phosphodiesterase 5 inhibitor and hence accumulation of guanosine cyclic monophosphate (cgmp). on the other hands, the nitric oxide/cgmp signaling pathway has crucial role in synaptic plasticity processes like long-term potentiation (ltp) in the central nervous system considered as a model of learning ...

Several data have shown that the neural cell adhesion molecule (NCAM) is necessary for long-term memory formation and might play a role in the structural reorganization of synapses. The NCAM, encoded by a single gene, is represented by several isoforms that differ with regard to their content of alpha-2,8-linked sialic acid residues (PSA) on their extracellular domain. The carbohydrate PSA is k...

Abacus experts exhibit superior short-term memory for digits, but the underlying neurophysiological mechanism remains unknown. Using event-related fMRI, we examined the brain activity of abacus experts and non-experts during the memory retention period of a delayed match-to-sample task using digits as stimuli. In controls, activity was greater in cortical areas related to verbal working memory,...

In a simulated aircraft navigation task, a fusion technique known as triangulation was used to improve the accuracy and onscreen availability of location information from two separate radars. Three experiments investigated whether the reduced cognitive processing required to extract information from the fused environment led to impoverished retention of visual-spatial information. Experienced p...

In a simulated aircraft navigation task, a fusion technique known as triangulation was used to improve the accuracy and onscreen availability of location information from two separate radars. Three experiments investigated whether the reduced cognitive processing required to extract information from the fused environment led to impoverished retention of visual-spatial information. Experienced p...

24 Although intermixing different motor learning tasks via random schedules enhances long-term 25 retention compared to “blocked” schedules, the mechanism underlying this contextual interference effect 26 has been unclear. Furthermore, previous studies have reported inconclusive results in individuals post27 stroke. 28 29 We instructed participants to learn to produce three grip force patterns ...

We report a functional imaging study of drawing cartoon faces. Normal, untrained participants were scanned while viewing simple black and white cartoon line drawings of human faces, retaining them for a short memory interval, and then drawing them without vision of their hand or the paper. Specific encoding and retention of information about the faces were tested for by contrasting these two st...

We report a functional imaging study of drawing cartoon faces. Normal, untrained participants were scanned while viewing simple black and white cartoon line-drawings of human faces, retaining them for a short memory interval, and then drawing them without vision of their hand or the paper. Specific encoding and retention of information about the faces was tested for by contrasting these two sta...

How long-term memories are stored is a fundamental question in neuroscience. The first molecular mechanism for long-term memory storage in the brain was recently identified as the persistent action of protein kinase Mzeta (PKMf), an autonomously active atypical protein kinase C (PKC) isoform critical for the maintenance of long-term potentiation (LTP). PKMf maintains aversively conditioned asso...