A method is described for computing patient-specific absorbed dose rates to active marrow which accounts for spatial variation in bone volume fraction and marrow cellularity. A module has been added to the 3D Monte Carlo dosimetry program DPM to treat energy deposition in the components of bone spongiosa distinctly. Homogeneous voxels in regions containing bone spongiosa (as defined on CT image...

BACKGROUND Somatostatin analogue-based radionuclide therapy with (177)Lu-DOTATATE is an important treatment option for patients with advanced neuroendocrine tumours overexpressing somatostatin receptors. In addition to the kidneys, the bone marrow is a major dose-limiting organ. The correlation between developed haematological toxicity and absorbed dose to the bone marrow is poor, which indicat...

monte carlo simulation is widely used in calculations involing transport of photons through different materials of different shapes. the method consists of randomly generating a finite set of photon histories over which the quantities of interest are averaged. in photon transport calculations, sampling the photon scattering angle from the klein-nishina probability distribution is of special imp...

Introduction: Internal radiation dosimetry is important from a radiation protection point of view and can help to optimize the radiation dose delivered to the workers, public, and patients. It has a rather simple protocol but needs a large amount of data. Therefore, it is difficult to do on a routine basis. The use of computer programs makes internal radiation dosimetry simpler...

Losso organspecific antigens has been shown to occur in epperimental and human carcinomas The present investigation, by serological and immunofluorescence methods, of a gastro-intestinal-specific antigen (Nairn et al., 1961; Nairn, 1962b) in human gastro-intestinal neoplasia demonstrates that loss of antigen is a feature of colonic and gastric carcinomas. Lesser degrees of depletion are found i...

Simple sets of equations have been derived to describe the absorption of microwave power in three-region, lossy transmission lines in terms of S-parameter reflection and transmission amplitudes. Each region was assumed to be homogeneous with discontinuities at the region boundaries. Different sets of equations were derived to describe different assumptions about the amplitudes of the reflection...

The pharmacokinetics, metabolism, and excretion of cobimetinib, a MEK inhibitor, were characterized in healthy male subjects (n = 6) following a single 20 mg (200 μCi) oral dose. Unchanged cobimetinib and M16 (glycine conjugate of hydrolyzed cobimetinib) were the major circulating species, accounting for 20.5% and 18.3% of the drug-related material in plasma up to 48 hours postdose, respectivel...

The pharmacokinetics, metabolism, and excretion of cobimetinib, a MEK inhibitor, were characterized in healthy male subjects (n = 6) following a single 20 mg (200 mCi) oral dose. Unchanged cobimetinib and M16 (glycine conjugate of hydrolyzed cobimetinib) were the major circulating species, accounting for 20.5% and 18.3% of the drug-related material in plasma up to 48 hours postdose, respectivel...