and is in no way intended to replace original scanned PDF. Neither Cengage Learning nor its licensors make any representations or warranties with respect to the machine generated PDF. The PDF is automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. CENGAGE LEARNING AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITH...

Currently there aren’t any remedies to target cancer cells selectively. Most drugs that exterminate rapidly proliferating cancer cells can also eradicate normal healthy cells. Even monoclonal antibodies (mAbs), present best treatment modalities in the targeted cancer immunotherapy, fail to destroy cancer cells specifically and a lot of mechanism-dependent or independent toxicities have been rep...

In this position paper we will motivate open issues in the context of domain-specific tailorability of software systems, as we have observed them in numerous projects. These issues are largely unresolved in today’s software engineering practices. However, we can identify a set of recurring forces in this context. Different interaction and programming techniques can be used to partially resolve ...

LIMITED DISTRIBUTION NOTICE: This report has been submitted for publication outside of the University of Colorado and will probably be copyrighted if accepted for publication. It has been issued as a Technical Report for early dissemination of its contents. In view of the transfer of copyright to the outside publisher, its distribution outside of the University prior to publication should be li...

Phenylthiourea (PTU) is commonly used for inhibiting melanization of zebrafish embryos. In this study, the standard treatment with 0.2 mM PTU was demonstrated to specifically reduce eye size in larval fish starting at three days post-fertilization. This effect is likely the result of a reduction in retinal and lens size of PTU-treated eyes and is not related to melanization inhibition. This is ...

objective: gastric cancer is a major health issue worldwide. using a therapeutic approach, with minor side-effects, is very essential for the treatment of the gastric cancer. shiraia bambusicola is a parasitic fungus which is widely used in china for curing several diseases with little side-effects. however, the mechanisms are not well understood yet. the aim of this study was to further unders...

An explanation was sought for the fact that delayed-type hypersensitivity (DTH) does not normally occur in response to T-cell-dependent antigens unless an adjuvant is used. But when sheep red blood cells (SRBC) were administered intravenously DTH did appear, provided that the dose of antigen was less than that required to give a maximum antibody response. Animals in which T-cell activity had be...

Impairments in metacognition, the ability to accurately report one's performance, are common in patients with psychiatric disorders, where a putative neuromodulatory dysregulation provides the rationale for pharmacological interventions. Previously, we have shown how unexpected arousal modulates metacognition (Allen et al., 2016). Here, we report a double-blind, placebo-controlled, study that e...

Renal cell carcinoma (RCC), arising from the proximal tubule in the kidney, accounts for approximately 85% of kidney cancers and causes over 140,000 annual deaths worldwide. In the last decade, several new therapies have been identified for treatment of metastatic RCC. Although these therapies increase survival time compared to standard care, none of them has curative properties. The nephrotoxi...

in this study tsga10 has been demonstrated as a testis-specific human gene that encodes a protein localized in sperm-tail and conserved in ciliary structure. further investigations showed tsga10 signalling and expression during embryogenesis, brain development and some malignancies including brain tumors. given the role of this protein in neuronal development and in certain tumors, it could pot...