When critically ill patients with pancreatitis develop infection of the pancreas, the ongoing management of such patients becomes difficult. Sufficient evidence supports the use of broad-spectrum antibiotic prophylaxis to prevent the development of bacterial infection. Since fungal infection is also a relatively common complication of severe pancreatitis--particularly when broad-spectrum antibi...

The infantile presentation of mitochondrial respiratory chain defects frequently simulates acute bacterial infection and sepsis. Consequently, broad spectrum antibiotic therapy is often initiated before definitive diagnosis is reached and without taking into consideration the potential harm of antibiotics affecting mitochondrial translation. Here, we demonstrate that some commonly used translat...

Antibiotics that interfere with DNA replication, as well as cell wall synthesis, induce the SOS response. In this report, we show that ciprofloxacin induces synthesis of colicins, narrow-spectrum antibiotics frequently produced by Escherichia coli strains, in an SOS-dependent manner.

introduction: stenotrophomonas maltophilia is a nosocomial multi drug resistant opportunistic pathogen which causes infections in vulnerable patients with cancer, cystic fibrosis and indwelling catheters. methods: 45 clinical s. maltophilia isolates were collected from blood samples and identified by biochemical tests. susceptibility to different antibiotics including co-trimoxazole, levofloxac...

b ackground : a cinetobacter spp. emerged as an opportunistic pathogen for hospital-acquired infections. recently, increasing antibiotic resistance among acinetobacter spp. has worsened the problem. the aim of this study was to investigate  the  emerging  trend  of  infection  due  to acinetobacter  in ghaem university hospital, mashhad during 2006-2012. methods : the demographic data and infor...

There are few reports of invasive infections caused by Brevundimonas vesicularis. We report two cases of B. vesicularis bacteremia confirmed by culture and 16S rRNA sequence analysis with highly variable sensitivity to broad-spectrum antibiotics. Initial empiric therapy with anti-pseudomonal antibiotics plus trimethoprim-sulfamethoxazole for hospital-acquired B. vesicularis infections should be...

The susceptibilities of 107 urinary isolates of coagulase-negative staphylococci to 19 antibiotics was determined by an agar dilution technique. Major differences in the antimicrobial susceptibilities of species of coagulase-negative staphylococci were observed. Staphylococcus epidermidis was more resistant to a wider spectrum of antibiotics than was Staphylococcus saprophyticus.

As Mycoplasma pneumoniae macrolide resistance grows and spreads worldwide, it is becoming more important to develop new drugs to prevent infection or limit disease. Because other mycoplasma species have acquired resistance to other classes of antibiotics, it is reasonable to presume that M. pneumoniae can do the same, so switching to commonly used antibiotics like fluoroquinolones will not resu...

BACKGROUND Excessive use of broad spectrum antibiotics is related to the spread of drug resistant bacterial strains in the community. AIM/METHODS The effects of immediate testing for C reactive protein (CRP) and white blood cell count (WBC) on physicians' choices of antibiotic was investigated in patients with acute infection. Acutely febrile new outpatients were randomised into two groups: g...

BACKGROUND The lack of prospective, randomized, controlled trial data to guide optimal antibiotic use in bacteraemic critically ill patients has led to a wide variety of strategies and major issues with drug resistance. We therefore prospectively investigated the epidemiology of bacteraemia and fungaemia in intensive care units (ICUs); and the impact of timing, type and appropriateness of antib...