The naturally occurring second messenger sphingosine (SPH) was examined for its ability to influence cardiac myocyte Ca2+ regulation. SPH inhibited intracellular Ca2+ transients in adult and neonatal rat ventricular myocytes. The inhibition was steeply dose dependent, with complete blockage of the Ca2+ transients occurring in the 20- to 25-mumol/L range. Whole-cell patch clamping revealed subst...

In this paper, we propose a novel method of interactive fluid simulating based on SPH, and implement it on CUDA (Compute Unified Device Architecture). Firstly we use SPH (Smoothed Particle Hydrodynamics) theory to simulate the motion of fluids. Secondly we propose an interactive method between fluid and rigid objects. We treat the rigid objects as two different types, static one and dynamic one...

In this paper, we present a Smoothed Particle Hydrodynamics (SPH) implementation algorithm on GPUs. To compute a force on a particle, neighboring particles have to be searched. However, implementation of a neighboring particle search on GPUs is not straightforward. We developed a method that can search for neighboring particles on GPUs, which enabled us to implement the SPH simulation entirely ...

Clip domain serine proteinase homologs are involved in many biological processes including immune response. To identify the immune function of a serine proteinase homolog (Sp-SPH), originally isolated from hemocytes of the mud crab, Scylla paramamosain, the Sp-SPH was expressed recombinantly and purified for further studies. It was found that the Sp-SPH protein could bind to a number of bacteri...

Sphingomyelin derivatives exert various second messenger actions in numerous tissues. Sphingosine (SPH) and sphingosine 1-phosphate (S1P) are two major sphingomyelin derivatives present at high levels in blood. The aim of the present work was to investigate whether S1P and SPH exert relevant actions in mouse skeletal muscle contractility and fatigue. Exogenous S1P and SPH administration caused ...

We introduce the idea of using an explicit triangle mesh to track the air/fluid interface in a smoothed particle hydrodynamics (SPH) simulator. Once an initial surface mesh is created, this mesh is carried forward in time using nearby particle velocities to advect the mesh vertices. The mesh connectivity remains mostly unchanged across time-steps; it is only modified locally for topology change...

Mathematical modeling of ice sheets is complicated by the nonlinearity of the governing equations and boundary conditions. Standard grid-based methods require complex front-tracking techniques and have a limited capability to handle large material deformations and abrupt changes in bottom topography. Consequently, numerical methods are usually restricted to shallow ice-sheet and ice-shelf appro...

Sphingosine-1-phosphate (Sph-1-P) is the initial product of catabolism of sphingosine by sphingosine kinase and is cleaved by Sph-1-P lyase to a fatty aldehyde and ethanolamine phosphate. This phosphorylated sphingoid base is not only an intermediary catabolite, but also a bioactive lipid with important functions, including stimulation of cell proliferation in Swiss 3T3 fibroblasts and inhibiti...

the current manuscript presents the validation of smoothed particle hydrodynamics (sph) techniques for wave generation by underwater explosion, utilizing the so-called dualsphysics numerical model. this numerical method is used to analyze generated waves which are initiated by man-made or natural explosions below free surface level of sea. in spite of the modeling limitations (e.g. absence of o...

We propose a novel SPH formulation for deformable solids. Key aspects of our method are implicit elastic forces and an adapted SPH formulation for the deformation gradient that—in contrast to previous work—allows a rotation extraction directly from the SPH deformation gradient. The proposed implicit concept is entirely based on linear formulations. As a linear strain tensor is used, a rotation-...