Background & Aim: Disabilities resulting from road accidents, especially spinal cord injury, which often occur in the early or middle ages of life, cause psychiatric symptoms and worsen the quality of life in these people. The present study aimed to determine the role of depressed mood in the quality of life of patients with spinal cord injury in Guilan Province (in the north of Iran)...

Inosine is a naturally occurring purine nucleoside, the effect of which was discovered only in recent decades. It has potential to prevent neuronal and glial death and can stimulate axonal outgrowth. This study evaluated the effect of inosine (400 mg per rat) administered orally two hours after experimental spinal cord injury and continuously daily for 12 days. We observed the effect of inosine...

OBJECTIVE To investigate changes in the core temperature and body surface temperature in patients with incomplete spinal cord injuries (SCI). In incomplete SCI, the temperature change is difficult to see compared with complete spinal cord injuries. The goal of this study was to better understand thermal regulation in patients with incomplete SCI. METHODS Fifty-six SCI patients were enrolled, ...

Spinal Cord Injury .........................................1-3 Implementation Of The Year 2000 AgeAdjustment Standard ....................................4-6 Spinal Cord Injury (SCI) is one of the most debilitating types of trauma. Disability, loss of productivity, extreme use of medical resources, and untold human suffering routinely accompany these injuries. In order to assess the need for s...

Spinal cord injury (SCI) is a neurologic disorder that have a significant impact on quality of life, life expectancy, and economic burden. SCI leads to irreversible neuronal loss and ultimately leads to paralysis. Mesenchymal stem cells (MSCs) are a promising source for cellular therapy because they have possessed the capacity of self-renewal and differentiation to several distinct mesenchymal ...

Compression injuries of the murine spinal cord are valuable animal models for the study of spinal cord injury (SCI) and spinal regenerative therapy. The calibrated forceps model of compression injury is a convenient, low cost, and very reproducible animal model for SCI. We used a pair of modified forceps in accordance with the method published by Plemel et al. (2008) to laterally compress the s...

Spinal cord injury (SCI) is the major cause of severe disability worldwide, which leads to neuron death, neuronal degeneration, and functional changes in spinal cord. Eucommia ulmoides extract (EUE) composed multiple iridoids phenols possesses anti-oxidative anti-inflammatory effects various pathologies. This study aims evaluate EUE on SCI underlying mechanisms. Male adult Sprague-Dawley rats (...

Background: Spinal cord injury (SCI) stimulates an inflammatory reaction that causes substantial secondary damage inside the injured spinal tissue. The purpose of this study was to determine the anti-inflammatory effects of epigallocatechin gallate (EGCG) on traumatized spinal cord. Methods: Rats were randomly divided into four groups of 12 rats each as follow: sham-operated group, trauma group...

Spinal cord injury (SCI) is a nervous system disease characterized by sensory and motor dysfunction, axonal apoptosis, decreased vascular density, inflammation. At present, surgical treatment, drug cell therapy can be used. Surgical treatment improve independent function scores, promote the recovery of neurons in spinal cord, but only symptoms. Complete SCI has not yet been achieved. However, d...