نتایج جستجو برای: spirooxindole
تعداد نتایج: 116 فیلتر نتایج به سال:
BACKGROUND The spiro- indole-pyrrolidine ring system is a frequently encountered structural motif in many biologically important and pharmacologically relevant alkaloids. The derivatives of spirooxindole ring systems are used as antimicrobial, antitumour agents and as inhibitors of the human NKI receptor besides being found in a number of alkaloids like horsifiline, spirotryprostatin and (+) el...
A series of new spiro-heterocycles engrafted spirooxindole/pyrrolidine/thiochromene scaffolds was synthesized by the three-component 1,3-dipolar cycloaddition reactions in a fully controlled regio- and stereo-selective fashion. Condensation several substituted isatin derivatives with L-proline generated azomethine ylides which subsequently reacted chalcones based thiochromene scaffold, finally ...
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