P. F. Lovibond and D. R. Shanks (2002) suggested that all forms of classical conditioning depend on awareness of the stimulus contingencies. This article considers the available data for eyeblink classical conditioning, including data from 2 studies (R. E. Clark, J. R. Manns, & L. R. Squire, 2001; J. R. Manns, R. E. Clark, & L. R. Squire, 2001) that were completed too recently to have been cons...

In this inaugural paper, we shall provide an overview of the endothelial surface layer or glycocalyx in several roles: as a transport barrier, as a porous hydrodynamic interface in the motion of red and white cells in microvessels, and as a mechanotransducer of fluid shearing stresses to the actin cortical cytoskeleton of the endothelial cell. These functions will be examined from a new perspec...

Memory can be divided into two categories: memory of events or facts, and memory for skills and rules. These are often called declarative memory and procedural memory (Squire, 1986; Tulving, 1985), or they are often characterized as ‘‘what’’ memory and ‘‘how’’ memory. An accumulation of declarative memories will comprise knowledge; an accumulation of procedural memories will comprise intelligen...

There is no reasonable doubt that the hippocampus plays an important role in memory processing. A virtually uncountable number of studies in animals and humans have revealed changes in neural activity in this structure during memory formation [Squire LR. Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. Psychol Rev 1992;99:195-231; Squire LR, Stark CE, Clark ...

bainitic transformation at low transformation temperatures leads to a microstructure involving fine plates of bainitic ferrite and thin films of retained austenite. this microstructure has shown ultimate tensile strength of about 2.2 gpa, noticeable uniform elongation in the range of 5 to 30%, hardness values of about 600 to 670 hv and impact toughness in the range of 30 to 40 mpa m1/2. with ca...

For the past 50 years, psychologists have wrestled with questions regarding the relationship between conscious awareness and human conditioned behavior. A recent proposal that the hippocampus mediates awareness during trace conditioning (Clark, Squire, Science 1998;280:77–81) has extended the awareness-conditioning debate to the neuroscience arena. In the following commentary, we raise specific...

Despite significant progress, new therapeutic approaches for advanced non-small cell lung cancer (NSCLC) are highly needed, particularly for the treatment of patients with squamous cell carcinoma. The epidermal growth factor receptor (EGFR) is often overexpressed in NSCLC and represents a relevant target for specific treatments. Although EGFR mutations are more frequent in non-squamous histolog...

Yonelinas et al. (2002) found that hypoxic patients exhibited deficits in recollection that left familiarity relatively unaffected. In contrast, Manns, Hopkins, Reed, Kitchener, and Squire (2003) studied a group of hypoxic patients who suffered severe and equivalent deficits in recollection and familiarity. We reexamine those studies and argue that the discrepancy in results is likely due to di...