Background Suppression Subtractive Hybridization (SSH) is an established method for separating DNA molecules that distinguish two closely related DNA samples, which has become a powerful method for generating subtracted cDNA libraries. In this study, we postulated that SSH could be used to identify significant genetic differences between Mycobacterium tuberculosis causing meningitis and M. tube...

Deformities in the Circle of Willis (CoW) can significantly increase the risk of cerebrovascular disease in humans. However, the molecular mechanisms underlying these deformities have not been understood. Based on our previous studies, variations in the CoW of gerbils are hereditary. A normal CoW is observed in approximately 60% of gerbils, a percentage that also applies to humans. Thus, gerbil...

During animal cell chemotaxis, signalling at the plasma membrane induces actin polymerisation to drive forward cell movement. Since the cellular pool of actin is limited, efficient protrusion formation also requires the coordinated disassembly of pre-existing actin filaments. To search for proteins that can monitor filamentous and globular actin levels to maintain the balance of polymerisation ...

The CLEF-SSH simulation project is an international collaboration , involving the IAS, LATT and the University of Sussex, to produce large hydrodynamic simulations of large-scale structure that implement realistic models of radiative gas cooling and energy feedback. The objective is to use these simulations to study the physics of galaxy clusters and to construct maps of large angular size of t...

This paper discusses our recent results in the classification of human-based ssh traffic as compared to machine-based scp traffic. Since both of these services, ssh and scp, use the same port, port 22, this classification problem occurs within a quite natural framework. Results that illustrate an exploratory analysis of the data will be presented along with some preliminary classification results.

The paper investigates the relationship between offshoring, wages, and the ease with which individuals’ tasks can be offshored. Our analysis relates to recent theoretical contributions arguing that there is only a loose relationship between the suitability of a task for offshoring and the associated skill level. Accordingly, wage effects of offshoring can be very heterogeneous within skill grou...

[1] Sea surface height (SSH) measurements from the Geosat satellite altimetry mission are analyzed to statistically characterize their noise process, which is defined here as the small-scale (<50 km), timevarying component of the altimetry data. This analysis is one component of a larger effort to extract meaningful information about seafloor roughness from the small-scale fabric of the altimet...