Background Selective serotonin reuptake inhibitors (SSRIs) have been observed to drive programmed cell death in Burkitt lymphoma cells. Accordingly, they were proposed as a new modality in the treatment of Burkitt lymphoma. However, they induce apoptosis with little if any appreciable selectivity. Actually, the selectivity appears to be so low that SSRIs can also kill protozoa (such as Trichomo...

Selective serotonin reuptake inhibitors (SSRIs) are reported to be associated with increased bleeding tendency. While findings of recent studies explain a lot about the pathophysiology of this side-effect, there is a general tendency to discontinue SSRIs as harmful medications. We report two instances of dose-dependent relations between sertraline and bleeding tendency. Bleeding diathesis was a...

(―SSRIs‖). 3 The study consisted of a thorough review of published and unpublished controlled clinical trials of antidepressants, and involved nearly 4,400 children and adolescents. 4 The results of the study suggested that suicidal behavior and ideation was twice as likely in children with Major Depressive Disorder (―MDD‖) who were prescribed off-label SSRIs. 5 Though the results were statisti...

Selective serotonin reuptake inhibitors (SSRIs) are reported to be associated with increased bleeding tendency. While findings of recent studies explain a lot about the pathophysiology of this side-effect, there is a general tendency to discontinue SSRIs as harmful medications. We report two instances of dose-dependent relations between sertraline and bleeding tendency. Bleeding diathesis was a...

Introduction Dysfunction in the brain serotonergic (5-HT) system is thought to underlie human depression. Selective Serotonin Re-uptake Inhibitors (SSRIs) are widely used antidepressant drugs whose therapeutic onset are delayed for several weeks whilst neuroadaptive changes take place in the brain, after which the previously disturbed serotonergic neurotransmission is restored. A suggested way ...