Stem cells from human exfoliated deciduous teeth (SHED) have been introduced recently and possess characteristics similar to mesenchymal stem cells (MSCs). Because of their convenient accessibility and safety of harvest, SHED can be a preferable source for the ever-increasing MSCs' applications  While they are new, their immunoproperties have not been adequately studied. In this study, we aimed...

To investigate the biocompatibility of the biomaterial, polylactic acid (PLA) with stem cells from human exfoliated deciduous teeth (SHED) and its induction of mineralization as a type of scaffold material. To determine the impacts of biomaterial PLA on proliferation and mineralization of SHED, the expression of surface molecules of SHED isolated and cultured in vitro was detected by flow cytom...

89 The first document of the American Academy of Pediatric Dentistry, “Policy on Stem Cells”, published in 2008, was aimed at providing dentists with information about the possible use of dental stem cells of their patients Stem cells constantly differentiate and create new specialised cells to replace the dead ones and to repair and regenerate tissues. Adult stem cells can be found in every ti...

objective: by date investigations have indicated the presence of stem cells within the pulp tissue of both temporary and permanent human teeth. in the present study, these stem cells were compared in terms of their growth kinetics and culture requirements. materials and methods: stem cells within the pulp of the human third molar (permanent tooth) and the deciduous incisor (temporary tooth) wer...

Introduction: Human exfoliated deciduous teeth–derived stem cells (SHEDs) have been shown as an excellent source of bone regeneration. Interleukin-17A (IL-17A) facilitates differentiation in various cell types, including SHEDs. In this study, we demonstrated IL-17A’s stimulating effect on SHEDs osteogenic and further evaluated the role ERK/MAPK signaling pathway process. Methods: The function I...

In the present study we have isolated and identified mesenchymal stem cells (MSCs) from the exfoliated deciduous teeth dental pulp (DP-MSCs), as plastic-adherent, spindle-shaped cells with a high proliferative potential. Immunophenotype analyses revealed that DP-MSCs were positive for mesenchymal cell markers (CD90, CD44, CD105, STRO-1, vimentin and α-SMA), and negative for hematopoietic stem c...

BACKGROUND: Pulp damage can lead to dentinogenesis impairment, irreversible pulpitis, or pulp necrosis. Despite being the most used endodontic procedure treat damaged pulp, root canal therapy only results in nonvital teeth which are prone fractures and secondary infection. Pulp-dentin regeneration has a potential regenerate structure similar normal pulp-dentin complex, be achieved by combining ...