The stepwise mutation model, which was at one time chiefly of interest in studying the evolution of protein charge-states, has recently undergone a resurgence of interest with the new popularity of microsatellites as phylogenetic markers. In this paper we describe a method which makes it possible to transfer many population genetics results from the standard infinite sites model to the stepwise...

The in vivo mechanics of the annulus fibrosus of the intervertebral disc is one of biaxial rather than uniaxial loading. The material properties of the annulus are intimately linked to the osmolarity in the tissue. This paper presents biaxial relaxation experiments of canine annulus fibrosus tissue under stepwise changes of external salt concentration. The force tracings show that stresses are ...

New approaches are currently being developed to expose biochemistry and molecular biology undergraduates to a more interactive learning environment. Here, we propose a unique project-based laboratory module, which incorporates exposure to biophysical chemistry approaches to address problems in protein chemistry. Each of the experiments described herein contributes to the stepwise process of iso...

Evolutionary aspects of high mutation pressure were studied in laboratory populations of Drosophila melanogaster that have irradiation histories up to 600 generations. Dose-response regressions for the x-ray induction of various types of mutation were obtained from six of these populations. The sensitivity of these irradiated populations relative to an unirradiated control population was charac...

Abs t rac t . The notion of institution is dissected into somewhat weaker notions. We introduce a novel notion of institution morphism, and characterize preservation of institution properties by corresponding properties of such morphisms. Target of this work is the stepwise construction of a general framework for translating logics, and algebraic specifications using logical systems. Earlier tr...

Basically, using the phrase “iterative” means there is a stepwise movement towards a (the) goal, instead of a “momentary leap” from problem to solution, where, at intervals, the situation is evaluated and necessary steps are taken to ensure the process is “on track” towards the solution. Such steps will normally be like loops, where you go backwards in the step-line and kind of “run it through ...

Shopping malls are one of the glories of metropolises with their attractive shops and a wide variety people who are walking in order to purchase goods. Location of a shopping mall is one of the critical criteria, because it can influence the success of the project. In addition, selecting an appropriate location to establish a new shopping mall is a sophisticated, time consuming and risky decisi...