The exciton coupled CD method has been applied to determine the absolute configuration of the diepoxins, spiroketaI-linked naphthodiepoxydecaIinones of fungal origin. The CD spectra of the bis-dimethylaminobenzoate derivatives of the diepoxins 71, land ~c, reveal a positive chiral twist between the two substituted hydroxyl groups and thus infer the $ configuration at both of these stereogenic c...

By using stereospecifically double-labelled radioactive mevalonates it was shown that betulaprenols-6 to -9, found in the woody tissue of Betula verrucosa, each contain three biogenetically trans-isoprene residues and that the remaining residues are biogenetically cis. The results obtained with these radioactive mevalonates also indicated that the activity of isopentenyl pyrophosphate isomerase...

Thanks to its atomand step-economy, C–H bond oxidation represents a “hot topic” in synthetic chemistry. However, due to the ubiquity of such bonds in organic molecules, regioand enantioselective C–H bond oxidation turns out to be extremely challenging, and efficient direct methods are in high demand. Compared to the success of aliphatic sp C–H oxidation by enzymes (such as cytochrome P450, Figu...

[structure: see text] The structure of ulapualide A (1) has been solved by X-ray crystallography in a complex with G-actin. The stereochemical configuration was assigned as 3S,9S,22S,23R,24S,26S,27S,31R,32R,33R.