نتایج جستجو برای: steroid 17
تعداد نتایج: 315698 فیلتر نتایج به سال:
Adrenal steroid secretion by cats has been studied by Bush (1951, 1953) and reviewed by Dorfman (1959). The cat adrenal secretes both cortisol and corticosterone. Arteta & Borrell (1958) and Borrell (1958) have reported studies of urinary excretion of 17-hydroxy corticosteroids (PorterSilber chromogens). Cats appear to excrete in urine very low concentrations of 17-hydroxy corticosteroids, all ...
17-α-hydroxylase enzyme has a crucial role in the steroid biosynthesis and, deficiency of this enzyme is an autosomal recessive monogenic disorder which is one of the two hypertensive form of congenital adrenal hyperplasia. It is characterized with the deficiency in glucocorticoid, adrenal androgen, and sex steroid synthesis with concomitant mineralocorticoid excess due to genetic defect in ste...
Myasthenia gravis (MG) was first described in 17(th) century. It was after 1960s, when it became clear that MG was an autoimmune disease targeting AChR. Recently, anti-MuSK and anti-Lrp4 antibodies were found as novel antibodies in MG. In 1980s, in addition to cholinesterase inhibitors, high-dose corticosteroid treatment was introduced. This dramatically reduced the mortality rate of MG, but no...
The interaction between two 14 beta steroids being still unsynthesized and a model receptor binding site is theoretically studied by a molecular mechanics scheme. Both compounds containing seven-membered rings in the 17 beta position are found to form stable hydrogen bonds to the receptor and can be attributed to be potential inhibitors of the Na+,K+-ATPase activity. Substantial steroid conform...
The 17 beta-hydroxysteroid dehydrogenases (17 beta HSDs) play an important role in the regulation of intracellular levels of biologically active sex steroid hormones in various human tissues. To date, eight distinctive 17 beta HSD enzymes have been cloned and characterized in humans. Among these isoenzymes, 17 beta HSD type 2 (17 beta HSD2) catalyses the conversion of testosterone into androste...
An inhibitor of adrenal steroid biosynthesis, aminoglutethimide, was administered to seven patients with low renin essential hypertension, and the antihypertensive action of the drug was compared with its effects on adrenal steroid production. In all patients aldosterone concentrations in plasma and urine were within normal limits before the study. Mean arterial pressure was reduced from a pret...
A sex steroid-binding protein (SBP) that binds to 17 b-estradiol with high affinity and moderate capacity was identified in the plasma of female and juvenile of kutum (Rutilus frisii kutum) sampled during the early stage of gonadal maturation in October and prior to spawning in March. Mean maximum specific binding (Bmax) and equilibrium dissociation constant (Kd) of the fish were as follows: In...
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