نتایج جستجو برای: stimulated gastric acid secretion
تعداد نتایج: 1032255 فیلتر نتایج به سال:
Helicobacter pylori may increase or inhibit gastric acid. We studied acid variations and plasma gastrin in cats harboring Helicobacter felis, harboring H. pylori, or free of gastric pathogens with reference to thioperamide (H(3) receptor antagonist) and SR-27417A (PAF receptor antagonist). In cats harboring H. felis, gastric mucosa were histologically normal. After H. felis eradication, pentaga...
A new compound, 2-phenyl-2-(2-pyridyl) thioacetamide (Fig. 1) with a powerful inhibitory effect on gastric secretion has recently been synthesised.' Bedi, Gillespie, and Gillespie (1967), using vagally innervated and Heidenhain pouch dogs, have shown it to inhibit gastrin-stimulated acid secretion. In that they failed to demonstrate any effect on histaminestimulated or amechol-stimulated gastri...
A new compound, 2-phenyl-2-(2-pyridyl) thioacetamide (Fig. 1) with a powerful inhibitory effect on gastric secretion has recently been synthesised.' Bedi, Gillespie, and Gillespie (1967), using vagally innervated and Heidenhain pouch dogs, have shown it to inhibit gastrin-stimulated acid secretion. In that they failed to demonstrate any effect on histaminestimulated or amechol-stimulated gastri...
The effect of cimetidine, a new histamine H2-receptor antagonist, on gastric acid secretion stimulated by a homogenised meal was studied in six normal volunteers using an in vivo intragastric titration technique. The subjects were studied twice, no more than 48 h apart, receiving either cimetidine 200 mg or placebo in random order. Cimetidine administered either 32 men before (three subjects) o...
Pituitary adenylate cyclase-activating polypeptide (PACAP), existing in two variants, PACAP-27 and PACAP-38, is found in the enteric nervous system and regulates function of the digestive system. However, the regulatory mechanism of PACAP on gastric acid secretion has not been well elucidated. We investigated the inhibitory action of PACAP-27 on acid secretion and its mechanism in isolated vasc...
These experiments were performed to determine the importance of cephalic-vagal stimulation in the acid secretory response to eating in normal human subjects. Cephalic stimulation was induced by a modified sham feeding (MSF) technique, during which subjects chewed and expectorated appetizing food. The response to MSF was compared with that to gastric distention with 600 ml NaCl, glucose, or food...
Gastric acid secretion by parietal cells requires trafficking and exocytosis of H/K-ATPase-rich tubulovesicles (TVs) toward apical membranes in response to histamine stimulation via cyclic AMP elevation. Here, we found that TRPML1 (ML1), a protein that is mutated in type IV mucolipidosis (ML-IV), is a tubulovesicular channel essential for TV exocytosis and acid secretion. Whereas ML-IV patients...
A dose response study of the effect of an octapeptide somatostatin analogue, SMS 201-995, on meal stimulated gastric acid secretion was carried out in 12 healthy volunteers. Infusion of SMS 201-995 in a dose of 50 pmol/kg/h almost completely abolished the acid response to the meal. Pl-gastrin was significantly decreased during infusion of 10 pmol/kg/h of SMS 201-995 and insulin was significantl...
The maladies of gastric secretion, including peptic ulcer disease, gastritis, and esophageal reflux, represent common and pervasive disorders throughout our population. Investigations during the past two decades have led to remarkable and profound changes in the treatment of acid-peptic disorders. Medical treatments have evolved from gastric resection through the evolution of "physiological" an...
In nonstimulated rabbit gastric glands, acetylsalicylic acid (10-500 microM) and indomethacin (3-300 microM) did not significantly modify the basal rate of acid secretion, whereas diclofenac and piroxicam (10-1,000 microM each) caused a marked and dose-dependent inhibitory effect (EC(50) = 138 and 280 microM, respectively). In gastric glands stimulated by histamine (100 microM), diclofenac also...
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