The bone morphogenetic proteins, (BMP)s are regulatory peptides that have significant effects on the growth and differentiation of gastrointestinal tissues. In addition, the BMPs have been shown to exert anti-inflammatory actions in the gut and to negatively regulate the growth of gastric neoplasms. The role of BMP signaling in the regulation of gastric metaplasia, dysplasia and neoplasia has b...

Gastrointestinal stromal tumors (GIST) are the most common primary mesenchymal neoplasms of the GI tract [1]. GISTs are KIT-positive and KIT-signalling driven neoplasms that most commonly originate in the stomach and small bowel but may occur at any site along the GI tract [2]. GISTs are uncommon in the colon and rectum (5-10%) [2]. Somatic mutation in the cKIT (~80%) [3,4] and PDGFRA (~10%) [5...

Japan has a unique position among industrialized countries as regards cancer mortality. For example, Japan is among the countries with the highest mortality from stomach cancer and the lowest for breast cancer1). Evidence has been given recently that some 80-90% of cancers can be related to environmental influences within a very broad definition2). Therefore, the international differences in ca...

Primary bladder tumor is a frequent urological malignancy, whereas the incidence of secondary bladder tumor from a distant organ is quite rare. Secondary bladder neoplasms represent no more than 3% of all malignant bladder tumors in surgical specimens, of which distant metastases from stomach account for about 4%. The signs of bladder neoplasm in a patient with malignancy elsewhere should alarm...

Patients with mucosa-associated lymphoid tissue (MALT) lymphoma often have multiple sites of disease at initial diagnosis or during the clinical course. The neoplasms at multiple sites are often presumed to be identical, indicating dissemination or relapse. However, evidence to support this presumption is usually not available. We compared IGH VDJ sequences in 4 patients with 2 sequential sites...

A comparative study was made on mortality during a 15-year period from 1968 to 1982 between atomic bomb survivors resident in Hiroshima Prefecture and non-exposed controls. The mortality rate for all causes of death was lower in atomic bomb survivors than in the non-exposed, but the rate was higher among those directly exposed within about 1 km than in the non-exposed. The mortality rate for ma...

BACKGROUND Emerging data suggest asymptomatic gastrointestinal stromal tumours (GISTs) of the upper gastrointestinal (UGI) tract are not uncommon. We sought to determine their incidence in patients undergoing resection for UGI neoplasms and their impact on surgical and adjuvant treatment. METHODS We accessed a database prospectively listing all patients undergoing resection of non-GIST neopla...

H YPOPROTEINEMIA occurs with greater frequency in patients with gastric cancer than in patients with other neoplasms or with benign lesions of the gastro-intestinal tract. This was noted earlier by various authors, and has been studied in this laboratory. Hypoproteinemia becomes more pronounced and resistant to therapy following surgical treatment for cancer of the stomach than following simila...

BACKGROUND Gastrointestinal stromal tumors (GISTs) and adenocarcinoma are distinct neoplasms originating from different cell layers. Approximately 20% of patients with GIST develop other cancers. CASE PRESENTATION We report a case of the coexistence of adenocarcinoma and gastrointestinal stromal tumor (GIST). Gastric endoscopy showed the ulcerated tumor with bleeding along the lesser curvatur...

Mortality or incidence rates of ten major neoplasms in migrants from several countries, their respective countries of origin, their Americanborn offspring, and United States whites were compared. Rates in suc ceeding generations of Americans increased most rapidly for colon cancer and most slowly for breast cancer, with ovarian cancer occupying an intermediate position and prostate cancer showi...