The Churg-Strauss syndrome (CSS), also called allergic granulomatosis and angiitis, is a multisystem disorder characterized by allergic rhinitis, asthma, and prominent peripheral blood eosinophilia. CSS is classified as a vasculitis of the small and medium sized arteries, which commonly involve the lung, the skin and the peripheral nerves and it is associated to ANCA in 40-60 percent (Sinico & ...

Allergic granulomatous angiitis (Churg-Strauss syndrome) is a variant of systemic vasculitis characterized by pulmonary and systemic small vessel vasculitis, extra-vascular granulomas and eosinophilia. Clinical features include presence of asthma and/or allergic rhinitis with constitutional symptoms such as fever and weight loss. Multisystem involvement includes pulmonary infiltrations, m...

INTRODUCTION Churg-Strauss syndrome is a vasculitis of medium to small sized vessels. Diagnosis is mainly clinical with findings of asthma, eosinophilia, rhinosinusitis and signs of vasculitis in major organs. CASE PRESENTATION We present a case of a 19-year-old Persian male who developed signs and symptoms of this syndrome related to hyposensitization treatments for allergy control. CONCLU...

Churg-Strauss syndrome, which has been frequently described by physicians in the literature, is a small and medium-sized vessel systemic vasculitis typically associated with asthma, lung infiltrates, and hypereosinophilia. We report a case of Churg-Strauss syndrome with presenting symptoms of bilateral lower limb weakness and numbness only. The patient was admitted to an orthopaedic ward for ma...

Spontaneous coronary artery dissection is a very rare event and occurs most often in young women following childbirth. It is also known as a rare focal complication in Churg-Strauss syndrome. Here, we present the case of a 43-year-old woman who died after spontaneous dissection of all three coronary arteries. The microscopic examination of coronary vessels showed severe eosinophilic infiltratio...

Leukotriene receptor antagonists (LTRA) are widely used in the treatment of asthma. Over the years, case reports have suggested a possible link between their introduction and the development of Churg–Strauss syndrome. The case we describe highlights a strong temporal relationship between the initiation of montelukast and appearance of features suggestive of Churg–Strauss syndrome; our patient w...

Churg-Strauss syndrome is a small and medium vessel vasculitis that is also known as allergic granulomatous angiitis. It most commonly presents with an asthma like symptoms. It was first described in Mount Siani Hospital, New York in 1951 by Jacob Churg and Lotte Stauss and was recognised after the study of a series of 13 patients who had asthma, eosinophilia, granulomatous inflammation necroti...

Leukotriene receptor antagonists (LTRA) are widely used in the treatment of asthma. Over the years, case reports have suggested a possible link between their introduction and the development of Churg–Strauss syndrome. The case we describe highlights a strong temporal relationship between the initiation of montelukast and appearance of features suggestive of Churg–Strauss syndrome; our patient w...

OBJECTIVE To study the long term effectiveness of intravenous immunoglobulin and plasmapheresis associated with prednisone and cyclophosphamide in Churg-Strauss syndrome. SUBJECTS and methods: We studied 18 subjects with new onset Churg-Strauss syndrome. All received the "standard" treatment based on prednisone (1 mg/kg/day for 1 month and then slowly tapered) and cyclophosphamide (2 mg/kg/da...

Churg-Strauss syndrome (CSS) is a rare multisystemic disorder of unknown origin and cardiac involvement is one of the most serious manifestations of the disease, accounting for approximately one-half of deaths attributable to CSS. Cardiac manifestation can be acute and mimic acute coronary syndrome (ACS). In this setting checking the blood leucocyte count can reveal hypereosinophilia and lead t...