PURPOSE Because recent studies indicate that blocking the interaction between p53 and Mdm2 results in the nongenotoxic activation of p53, the authors sought to investigate whether the inhibition of p53-Mdm2 binding activates p53 and sensitizes human retinal epithelial cells to apoptosis. METHODS Apoptosis was evaluated by the activation of caspases and DNA fragmentation assays. The Mdm2 antag...

Insect hemocytes have been the focus of researchers for decades (e.g., Jones, 1962; Ravindranath, 1978; Hall, 1983; Ribeiro & Brehelin, 2006). Most research has sought to increase our understanding of what factors influence hemocytes numbers, especially in response to various stressors (e.g., Silva et al., 2002; Andrade et al., 2003; Mochiah et al., 2003). Moreover, the recent increase in quest...

research-article Free AccessCOVID-19 modeling for India and a roadmap the future Authors: Siva Athreya Indian Statistical Institute, Bengaluru, IndiaView Profile , Gautam I. Menon Ashoka University in Haryana, Rajesh Sundaresan Institute of Science Authors Info & Claims Communications ACMVolume 65Issue 11November 2022 pp 82–87https://doi.org/10.1145/3557798Published:20 October 2022Publication H...

Implications for adults' fitness through the foliage effects of five different host plants on larval survival and performance of the lappet moth, Streblote panda Hübner (Lepidoptera: Lasiocampidae), as well as their effect on species fitness were assayed. Larvae were reared under controlled laboratory conditions on excised foliage. Long-term developmental experiments were done using first insta...