Abstract. We address in this paper the problem of filtering three-dimensional sparse data representing real objects. The main application is to eliminate points that are not structured on surfaces. Points classified as organized can be the input for other processes. An accumulation process infers the organization of each input element. The tensorial fields used in our method act as three-dimens...

Lithography-based additive manufacturing technologies have become a valuable tool in tissue engineering for the fabrication of biocompatible and biodegradable bone regeneration scaffolds. Currently employed photopolymers based on (meth)acrylates, vinyl esters, or carbonates display undesirable properties such as irritancy cytotoxicity residual monomers, degradation via autocatalytic bulk erosio...

objective: the bioscaffold can be used in tissue engineering and regenerative medicine. the scaffolds used in tissue engineering must have high porosity to facilitate accelerated angiogenesis for feeding cells and repelling cell waste outside the scaffold. in this experimental study, we attempted to produce lung three-dimensional scaffold and assay its effect on cell penetration and migration. ...

aligned and random nanocomposite nanofibrous scaffolds were electrospun from polycaprolactone (pcl), poly (vinyl alcohol) (pva) and hydroxyapatite nanoparticles (nha). the morphology and mechanical characteristics of the nanofibers were evaluated using scanning electron microscopy and tensile testing, respectively. scanning electron microscopy revealed fibers with an average diameter of 123 ± 3...

The authors present a comprehensive treatment guide to nasal septal perforations. Successful surgical repair requires vascularized tissue flaps, interpositional tissue scaffolding, and tension-free closure. However, surgical techniques vary with the size of the defect, and there is no single universally effective procedure.

in this study, porous scaffolds from poly(d,l-lactic acid) have been prepared via liquid- liquid phase separation method in ternary system of polymer-1,4-dioxane-water. polymer dissolved in dioxane in 1.5, 2.5 and 5 % wt/v and the solvent/non-solvent ratios were 13/87, 15/85 and 17/83. cloud point curves prepared by visual turbidometry. in order to obtain porous scaffolds with inter-connected p...

abstract due to their mulitpotency, mesenchymal stem cells (mscs), have the ability to proliferate and differentiate into multiple mesodermal tissues. the aim of this study was to isolate mscs from human umbilical cord (hucmscs) to determine their osteogenic potential on nanofibrous scaffolds. to this end, poly (l-lactic acid) (plla)/nano hydroxyapatite (ha) composite nanofibrous scaffolds were...

A new GRID-based method for scaffold hopping (SHOP) is presented. In a fully automatic manner, scaffolds were identified in a database based on three types of 3D-descriptors. SHOP's ability to recover scaffolds was assessed and validated by searching a database spiked with fragments of known ligands of three different protein targets relevant for drug discovery using a rational approach based o...

Stem cell research has obtained much prominence in recent years for its therapeutic potential in dealing with serious diseases, many of which are essentially incurable by routine therapies. Mesenchymal stem cells with pluripotency and immunomodulatory properties are suitable candidates for tissue engineering and regenerative medicine. Today, nanofibrous scaffolds are widely used in tissue en...

Successful regeneration of biological tissues in vitro requires the utilization of three-dimensional (3D) scaffolds that provide a near natural microenvironment for progenitor cells to grow, interact, replicate, and differentiate to form target tissues. In this work, a rapid aqueous photo-polymerization route was developed toward the fabrication of a variety of polymer hydrogel 3D inverted coll...