Dendroaspis natriuretic peptide (DNP) shares a functionally important sequence homology with other natriuretic peptides. However, the characteristics of DNP and its receptor in the context of diabetes remafin to be fully elucidated. In the present study, alterations in the plasma levels and tissue contents of DNP and the properties of its receptor in diabetic rats, induced by streptozotocin (ST...

Prostaglandin E2 (PGE2) has been implicated to play a pathogenic role in diabetic nephropathy (DN) but its source remains unlcear. To elucidate whether mPGES-1, the best characterized PGE2 synthase, was involved in the development of DN, we examined the renal phenotype of mPGES-1 KO mice subjected to STZ-induced type-1 diabetes. After STZ treatment, mPGES-1 WT and KO mice presented the similar ...

Pflueger, Axel C., Timothy S. Larson, Siegfried Hagl, and Franklyn G. Knox. Role of nitric oxide in intrarenal hemodynamics in experimental diabetes mellitus in rats. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R725–R733, 1999.—The role of nitric oxide (NO) in the regulation of the intrarenal microcirculation in streptozotocin (STZ)-induced diabetes mellitus in rats is not c...

BACKGROUND Streptozotocin (STZ) is used as a common tool to induce diabetes and to study diabetes-induced complications including diabetic peripheral neuropathy (DPN). Previously, we have reported that STZ induces a direct effect on neurons through expression and function of the Transient receptor potential vanilloid 1 (TRPV1) channel in sensory neurons resulting in thermal hyperalgesia, even i...

The aim of this study was to determine the effects of balanced deep-sea water (BDSW) on hyperglycemia and glucose intolerance in streptozotocin (STZ)-induced diabetic mice. BDSW was prepared by mixing DSW mineral extracts and desalinated water to yield a final hardness of 1000-4000 ppm. Male ICR mice were assigned to 6 groups; mice in each group were given tap water (normal and STZ diabetic gro...

OBJECTIVE Abnormalities in the regulation of natriuretic peptides (NP) associated with major diseases such as hypertension, heart failure, and diabetes mellitus (DM) have been reported. We investigated levels of mRNA for the vasodilator C-type natriuretic peptide (CNP) in the renal cortex of streptozotocin (STZ)-diabetic rats and the influence of an angiotensin II inhibition. METHODS DM was i...

Highlights: This study observed the histology of pancreatic β-cell damage without any intervention to kidneys animal models. The histological analysis shows that STZ-induced models can be used for assessing kidney abnormalities due hyperglycemia. A scoring system was developed evaluate changes in cells. Abstract are one organs affected by microvascular complications diabetes mellitus. Hyperglyc...

Accumulating evidence indicates the association between changes in circulating sex steroid hormone levels and development of diabetic nephropathy. However, renal synthesis hormones during diabetes is essentially unknown. Male Wistar rats were injected with streptozotocin (STZ) or vehicle. After one week, no functional structural parameters related to kidney damage observed STZ group; however, a...

angiotensin-converting enzyme (ace) inhibitors appear to correct many of the abnormalities associated with the vascular dysfunction found in diabetic patients. in this respect, quinapril is a unique ace inhibitor with multiple protective effects. the present study was carried out to investigate the effect of intraperitoneal administration of quinapril on the aortic reactivity of streptozotocin ...

OBJECTIVE The present study was hypothesized to investigate the beneficial effects of fresh, aged, and cooked garlic extracts on blood glucose and memory of diabetic rats induced by streptozocine (STZ). MATERIAL AND METHODS Diabetes was induced by an intraperitoneal injection of STZ (60 mg/kg body weight). An oral dose of 1000 mg/kg of each garlic extract was given daily for 4 weeks after dia...