objective: chlorpyrifos (cpf) is a neurotoxic organophosphorus (op) insecticide. its mechanism of action includes oxidative stress, excitotoxicity, and inhibition of the acetylcholinesterase enzyme (ache). the aim of the present study is to investigate cpf toxicity in mature and immature cerebellar granule neurons (cgns), as well as its effect on glutamate induced excitotoxicity. materials and ...

Predictions of carcinogenic activity are made for 30 chemicals currently being assessed for rodent carcinogenicity by the U.S. National Toxicology Program. The predictions are based upon the chemical structure, the anticipated or reported mutagenicity, and the reported sub-chronic toxicity of each chemical. It is predicted that 13 chemicals will be noncarcinogenic to rodents, that 7 will be gen...

This study was carried out to investigate blood biochemical alteration in albino rats after cypermethrin treatment. Nitrogen contents of blood in the albino rats have been influenced by the amount of cypermethrin used for toxicity in the acute (1d) and sub chronic (7,14and21days) treatment in the present investigation. The free amino acid, total protein, urea, urea nitrogen, uric acid and creat...

423 A k-NN Algorithm for Predicting Oral Sub-Chronic Toxicity in the Rat Domenico Gadaleta 1,2, Fabiola Pizzo 1, Anna Lombardo 1, Angelo Carotti 2, Sylvia E. Escher 3, Orazio Nicolotti 2 and Emilio Benfenati 1 laboratory of environmental Chemistry and toxicology, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy; Dipartimento di Farmacia − Scienze del Farmaco, Università degl...