odontogenic keratocysts (okcs) are one of the most frequent features of nevoid basal cell carcinoma syndrome (nbs). it is linked with mutation in the ptch gene. partial expression of the gene may result in occurrence of only multiple recurring okc. our patient presented with nine cysts with multiple recurrences over a period of 11 years without any other manifestation of the syndrome.

The authors present a 21-year-old woman who has been receiving rapamycin for 5 months for bilateral subependymal giant cell astrocytomas. The patient was started at a dose of 0.2 mg/kg/day. Levels were maintained between 11 and 13 ng/mL. Magnetic resonance imaging of the brain 2(1/2) months after initiating rapamycin demonstrated a decrease in size of both astrocytomas (11 to 7.5 mm on the righ...

Objective: To report a case of subependymal giant cell astrocytoma (SEGA) in a patient with tuberous sclerosis, emphasizing the proton MR spectroscopy (MRS) findings. Case: A three year-old boy with tuberous sclerosis presented with a 3-month history of mild headache. The physical examination showed discrete mental retardation and multiple hypomelanic macules in the legs and back. MRI showed ma...

The rate of migration of immature granule cells of the rat olfactory bulb and polarity of cell-organelles in the migrating granule cells were investigated by 3H-thymidine autoradiographic and electron microscopic methods. The time lag in migration between two points was determined by cross-correlation analysis of labeling indices of the two areas. Granule cells were estimated to take 6 days to ...

Gravid Nya: NYLAR strain mice were infected with Toxoplasma gondii on embryonic day 7. During the remaining 12 days of gestation, considerable fetal wastage occurred. At birth, pups were sickly and growth-stunted, and postnatal mortality was high. After 1 month, surviving weanlings were killed and autopsied. Coronal sections of the cerebrum revealed: numerous cortical and periventricular cystic...

Subependymal nodular heterotopia (SNH) is a cortical development malformation that is commonly associated with medically resistant epilepsy. Cases of SNH are challenging to treat surgically because there are typically multiple nodules, which may be involved in epileptogenesis. Moreover, dual pathology may exist in these patients. Here, we present a case with unilateral subependymal heterotopic ...

Subependymal giant cell astrocytoma (SEGA) is a type of brain tumour that develops in 10-15% of individuals with tuberous sclerosis complex (TSC). SEGAs can be unilateral or bilateral, developing from benign subependymal nodules (hamartomas) located near the foramen of Monro. These are usually slow-growing, glialneuronal tumours that develop within the first 2 decades of life. Traditionally, th...

A review of MR and CT images in five patients, 8 months to 22 years old, diagnosed as having tuberous sclerosis, revealed linear abnormalities in the cerebral white matter. A linear abnormality connecting a subependymal nodule to a subcortical lesion was shown in two patients as an area of hypointensity on T1-weighted MR images and as an area of hyperintensity on T2-weighted images. These appea...

objective: oral lesions are among the important reasons for seeking dental care. being frequently encountered, giant cell lesions form an important group of oral lesions. the epidemiologic data on these lesions, however, is scarce in iran. the present study investigated epidemiological and demographic characteristics of giant cell lesions in oral biopsies done in one of the largest oral patholo...