Sixty patients with hypertensive urgency were subdivided into 3 groups of 20 patients each. The first group received sublingual captopril (25 mg), the second group received sublingual nifedipine (10 mg) and the third group received sublingual losartan (50 mg). In the captopril, nifedipine and losartan groups, the mean systolic pressures at the onset of hypertensive urgency were 188.00±23, 190.0...

OBJECTIVE The aim of the present study was to compare the analgesic efficacy of a single dose of sublingual piroxicam to that of a placebo during acute attacks of migraine without aura. METHODS The drug (N = 30) or a placebo (N = 30) was administered, on randomisation and double-blind basis, to 60 patients between 18 and 50 years of age suffering from migraine without aura. The patients were ...

BACKGROUND Sublingual nitroglycerin (glyceryltrinitrate, GTN) capsules or isosorbide dinitrate (ISDN) spray are routinely used to treat anginal attacks and to vasodilate maximally the epicardial coronary arteries during coronary angiography. OBJECTIVE To compare the coronary vasodilatory effects of GTN capsules and ISDN spray with those induced by intracoronary GTN using quantitative coronary...

BACKGROUND Shivering and fever are common side effects of misoprostol. An unexpectedly high rate of fever above 40°C was documented among Ecuadorian women given treatment with 800mcg of sublingual misoprostol to manage postpartum hemorrhage (PPH) (36%). Much lower rates have been reported elsewhere (0-9%). METHODS From February to July 2010, an open-label pilot study was conducted in Quito, E...

BACKGROUND The pharmacokinetic parameters of four different routes of administration of a single dose of 400 microg of misoprostol were studied. METHODS A total of 40 women undergoing termination of pregnancy by suction evacuation was randomized by computer model to receive 400 microg of misoprostol by one of four routes: (i) sublingual (ii) oral (iii) vaginal and (iv) vaginal with addition o...

OBJECTIVE To compare the efficacy of the vaginal and sublingual administration of the synthetic prostaglandin misoprostol with the currently used oral administration route in second-trimester medical abortion. METHODS This was a prospective randomized trial of medical abortion with misoprostol after mifepristone priming at 14-24 weeks of gestation. From 2009 to 2013, recruited women received ...

BACKGROUND Assessment of the microcirculation is a promising target for the hemodynamic management of critically ill patients. However, just as the sole reliance on macrocirculatory parameters, single static parameters of the microcirculation may not represent a sufficient guide. Our hypothesis was that by serial topical application of acetylcholine (ACH) and nitroglycerin (NG), the sublingual ...

BACKGROUND Thyroid neoplasia is common in dogs, but there are few reports of dogs with ectopic, sublingual thyroid tumors. OBJECTIVES To describe clinical features and outcomes of dogs with ectopic, sublingual thyroid neoplasia. ANIMALS Five hundred and forty-four dogs with thyroid neoplasia. METHODS This retrospective study reviewed the medical records of dogs referred for thyroid neopla...

objective: in this study efficacy of sub lingual misoprostol was examined in comparison to oxytocin (i.v.) for inducing of labor in term pregnancy. materials and methods: seventy patients were allocated by blocked randomization to groups a (n=35, sub lingual misoprostol 25 μg four hourly to maximum of 5 doses) and b (n=35, continuous oxytocin infusion). results: delivery active phase and total ...