The endoplasmic reticulum stress response, also known as the unfolded protein response (UPR), has been implicated in the normal physiology of immune defense and in several disorders, including diabetes, cancer, and neurodegenerative disease. Here, we show that the apoptotic receptor CED-1 and a network of PQN/ABU proteins involved in a noncanonical UPR response are required for proper defense t...

Massive actuator arrays found their applications in robotics, pharmaceutics, aerospace, etc. Compared with electrically and/or pneumatically powered actuator array, hydraulic actuator has the comprehensive advantages of higher force density (i.e. force / actuation area), better controllability, and simpler remote control accessibility. This paper presents approaches to construct and control a m...

Resumo Objetivo: O presente artigo é uma revisão do conhecimento atual relativo às terapias somáticas em psiquiatria, com foco em transtornos psiquiátricos resistentes ao tratamento usual. Método: Foi realizada uma pesquisa computadorizada da literatura no Medline utilizando as palavras “eletroconvulsoterapia”, “estimulação magnética transcraniana”, “terapia magnética convulsiva”, “estimulação ...

Escherichia coli is the most common organism associated with asymptomatic bacteriuria (ABU). In contrast to uropathogenic E. coli (UPEC), which causes symptomatic urinary tract infections (UTI), very little is known about the mechanisms by which these strains colonize the human urinary tract. The prototype ABU E. coli strain 83972 was originally isolated from a girl who had carried it asymptoma...