Using a routine procedure, a number of derivatives of the benzo[4,5]isothiazolo[2,3-a]pyrazine-6,6-dioxide ring system have been synthesized from readily available starting materials. A series of chalcones were synthesized, which were subsequently reacted with chlorosulfonic acid to generate chalcone sulfonyl chlorides. The chalcone sulfonyl chlorides were then treated with bromine to generate ...

A mild, efficient synthesis of sulfonyl fluorides from aryl and heteroaryl bromides utilizing palladium catalysis is described. The process involves the initial palladium-catalyzed sulfonylation of aryl bromides using DABSO as an SO2 source, followed by in situ treatment of the resultant sulfinate with the electrophilic fluorine source NFSI. This sequence represents the first general method for...

The asymmetric Neber reaction of 3-O-sulfonyl ketoxime, in situ generated from isatin ketoxime and sulfonyl chloride, for the synthesis of chiral spirocyclic oxindole compounds is reported. With the developed protocol, a range of chiral spirooxindole 2H-azirines could be obtained in good to excellent yields and up to a 92 : 8 enantiomeric ratio by using (DHQD)2PHAL as the catalyst. This methodo...

The crystal structure of the title compound, C(14)H(11)ClN(2)O(2)S, features a three-dimensional network stabilized by π-π inter-actions between the rings of the 4-methyl-phenyl-sulfonyl protecting group [centroid-centroid distance = 3.623 (1) Å]. The 4-methyl-phenyl-sulfonyl ring makes a dihedral angle of 79.60 (6)° with the 4-chloro-1H-pyrrolo[2,3-b]pyridine unit.

Mol-ecules of the title compound, C(15)H(17)NO(2)S, which was synthesized from methane-sulfonyl chloride and dibenzyl-amine, are packed in anti-parallel arrays along the c axis, with the methyl group of one mol-ecule dovetailed between the two phenyl rings of the next mol-ecule. Along any such array, the sulfonyl O atoms protrude alternately up and down.

The structure of the title salt hydrate, K(+)·C(6)H(4)Cl(2)NO(2)S(-)·H(2)O, shows each of the sulfonyl O and water O atoms to be bidentate bridging. The hepta-coordinated K(+) cation is connected to two water O atoms, four sulfonyl O atoms and one Cl atom. The crystal structure comprises sheets in the bc plane which are further stabilized by O-H⋯N hydrogen bonds.

Phototaxis in Chlamydomonas reinhardi was specifically inhibited by azide. The effect of azide was rapid and reversible, and did not depend upon the intensity of actinic light. Under conditions of completely inhibited phototaxis, azide had no effect on the number of motile cells in the population or on the rate of motility. The effect was not related to changes in oxygen uptake or cellular ATP ...

In the crystal structure of the title compound, C(9)H(9)NO(3)S, there is distorted tetra-hedral geometry around the S atom. The sulfonyl group is almost normal to the benzene ring, while the carbonyl O atom and methyl C atom are on opposite sides of this ring. The heterocyclic ring adopts a half-boat conformation with the S atom out of the plane. The mol-ecules are dimerized by hydrogen bonding...

In the crystal structure of the title compound, C(14)H(12)ClNO(2)S, the mol-ecules display a trans conformation with respect to the C=N double bond. The dihedral angle between the methyl-sulfonyl benzene and chloro-benzene rings is 59.59 (8)°. The crystal packing is stabilized by weak C-H⋯O inter-actions and by π-π stacking inter-actions between inversion-related methyl-sulfonyl benzene rings [...

In title compound, C(14)H(12)N(2)O(5)S, the dihedral angle between the sulfonyl benzene ring and the -SO(2)-NH-C-O segment is 81.5 (2)° and that between the sulfonyl and the benzoyl benzene rings is 89.8 (1)°. In the crystal, mol-ecules are linked into chains along the b axis via inter-molecular N-H⋯O hydrogen bonds. C-H⋯O inter-actions are also observed.