Chitin-silica represents a potentially useful superdisintegrant in many pharmaceutical applications. The "intimate" association between chitin and silica, without evidence of chemical reaction, creates an insoluble, hydrophilic, highly absorbent inert material. The new superdisintegrant is characterized by superiority in water uptake and water penetration, with no gelling hindrance effects, as ...

Submitted 2011.09.28. Accepted for publication 2011.12.19. The convenience of administration and improved patient compliance are important in the design of oral drug delivery system which remains the preferred route of drug delivery inspite of various disadvantages. One such problem can be solved in the novel drug delivery system by formulating “mouth dissolving tablets” (MDTs) which disintegra...

Hydrogels are crosslinked polymers with the ability to swell in an aqueous medium. Crosslinking in hydrogels occurs by chemical or physical means depending on the polymer properties and experimental conditions. Owing to a large variety in chemical structure and crosslinking methods, various hydrogels have been prepared for various applications in pharmaceutical and biomedical fields. This chapt...

Introduction: Oro-dispersible tablets are rapidly dissolved in saliva without the need for water and beneficial renal impaired, bedridden psychiatric patients. Objective: The study aimed to formulate oro-dispersible of indomethacin with reduced adverse effects, better patient compliance, faster action, convenience Methods: were prepared using three different super disintegrants; crospovidone, c...

Objective: The present study was aimed to prepare and evaluate Donepezil HCl Orodispersible tablets (DO-ODTs) using natural synthetic superdisintegrants increase patient compliance. Methods: Direct compression adapted crospovidone, croscarmellose sodium as mucilage isolated from fruits of Abelmoschus esculentus at different concentrations along with microcrystalline cellulose aerosil. powder mi...