objective(s): amyotrophic lateral sclerosis (als), a fatal progressive neurodegenerative disorder, is the most common motor neuron disease in european populations. approximately 10% of als cases are familial (fals) and the other patients are considered as sporadic als (sals). among many als causing genes that have been identified, mutations in sod1 and c9orf72 are the most common genetic causes...

background: atopic dermatitis is a public health problem worldwide. increment of reactive oxygen species (ros) produc­tion may be one of the contributing factors of tissue damage in atopic dermatitis. the present study was designed to deter­mine the effect of vitamins e and/or d on erythrocyte superoxide dismutase and catalase activities in patients with atopic dermati­tis. methods: in a random...

superoxide dismutase (sod) is an important antioxidant that protects many types of cells from the free radical damage. one of the possible ways for the use of sod is its incorporation in liposomes. the aim of this study was to investigate the effect of cationic phospholipids on the entrapment of human erythrocyte superoxide dismutase (cu/zn sod) in liposomes. also, in the present study, we exam...

Superoxide dismutases might conceivably protect against both ionizing radiation and free radical-producing antibiotic antitumor drugs. Copperand zinc-containing Superoxide dismutase (CuZn Superoxide dismutase) and manganese-contain ing Superoxide dismutase (Mn Superoxide dismutase) were specifically assayed in human malignant tumors and for com parison in human tissues. The tumors possessed les...

The appearance of superoxide anion radical in cerebral extracellular space during and after acute hypertension induced by intravenous norepinephrine was investigated in anesthetized cats equipped with cranial windows. Superoxide was detected by demonstrating the presence of superoxide dismutase-inhibitable reduction of nitroblue tetrazolium. The superoxide dismutase-inhibitable rate of reductio...