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Macrophages produce reactive oxygen species and reactive nitrogen species that have potent antimicrobial activity. Resistance to killing by macrophages is critical to the virulence of Mycobacterium tuberculosis. M. tuberculosis has two genes encoding superoxide dismutase proteins, sodA and sodC. SodC is a Cu,Zn superoxide dismutase responsible for only a minor portion of the superoxide dismutas...

background: blood is permanently exposed to oxidation stress and therefore has a high antioxidants capacity. many different factors increasing the demand for the antioxidant capacity can be observed in the stored blood of donors. consequently, damage to erythrocytes by free radicals may occur. so it is useful to control the alternation of anti-oxidant enzymes in stored blood at different days o...

Superoxide dismutases might conceivably protect against both ionizing radiation and free radical-producing antibiotic antitumor drugs. Copper- and zinc-containing superoxide dismutase (CuZn superoxide dismutase) and manganese-containing superoxide dismutase (Mn superoxide dismutase) were specifically assayed in human malignant tumors and for comparison in human tissues. The tumors possessed les...

PURPOSE Retinal ischemia/reperfusion (I/R) injury results in the generation of reactive oxygen species (ROS). The aim of this study was to investigate whether delivery of the manganese superoxide dismutase gene (SOD2) or the catalase gene (CAT) could rescue the retinal vascular damage induced by I/R in mice. METHODS I/R injury to the retina was induced in mice by elevating intraocular pressur...

Cadmium (Cd) is a highly toxic pollutant and nonessential element for plant growth. Here, we investigated the levels of malondialdehyde (MDA), H2O2, sugars, activity gene expression antioxidant enzymes sugar metabolism-related in mycelia Pleurotus eryngii grown presence 0, 0.5, 1, 1.5, 2.0, 4.0 mg·L−1 Cd. Raising Cd concentration resulted increases, followed by decreases (MDA) H2O2 mycelia. The...