Enzymatic superoxide-dismutase activity is believed to be important in defense against the toxic effects of superoxide. Although superoxide dismutases are among the best studied proteins, numerous questions remain concerning the specific biological roles of the various superoxide-dismutase types. In part, this is because the proposed damaging effects of superoxide are manifold, ranging from ina...

The sequence encoding a superoxide dismutase (SOD) was isolated from the cDNA library of a zinc-tolerant strain of the ericoid mycorrhizal fungus Oidiodendron maius, grown under zinc-stress conditions. Sequence homology to other SODs strongly suggests that it is a copper- and zinc-containing SOD. Functional complementation assays showed that the gene confers increased tolerance to zinc and copp...

Coxiella burnetii was examined for superoxide anion (O2-) production and superoxide dismutase and catalase activities. The organism generated O2- at pH 4.5 but not at pH 7.4. The rickettsia displayed superoxide dismutase activity distinguishable from that of the host cell (L-929 mouse fibroblast). Catalase activity was maximal at pH 7.0 and diminished at pH 4.5. These enzymes may account, in pa...

Administration of bacterial endotoxin to rats exposed to greater than 95% O2 results in increased lung superoxide dismutase activity, decreased O2-induced lung damage, and a 3- to 4-fold improvement in survival rate (Frank, L., Yam, J., and Roberts, R. J. (1978) J. Clin. Invest, 61, 269-275). Antibodies to rat liver (Cu,Zn) superoxide dismutase were prepared and utilized to investigate the mech...

in order to investigate the effect of hexaconazole (hex) on the increasing tolerance to water deficit stress of two soybean (glycine max l.) cultivars, an experiment was conducted in faculty of agronomy of tarbiat modares university as factorial experiment in randomized complete block design arrangement. factors examined in this study were included soybean cultivars (l17 and clark63), hex conce...

conclusions the administration of 75 mg/kg/day cinnamon significantly increased the sperm population, motility and viability, which supports the theory that in mammalians, cinnamon has a beneficial effect on spermatogenesis. results sperm quality parameters, total serum testosterone, sod, cat, and gpx levels were significantly increased in the cinnamon group in comparison to controls (p < 0.05)...

background: blindness due to cataract is a major and important problem in pakistan. the problem is expected to increase in future due to increase in tobacco smoking. the aim of study was to look for the mechanism associated with metal deposition and its effect on antioxidant enzymes in lens of smokers in karachi, pakistan. methods: 20 cataract patients were randomly selected from out patient de...

Superoxide dismutase and catalase activities have been measured in cell-free extracts of calf trabecular meshwork, and for comparison, in calf iris, retina, lens, liver, and erythrocytes. Gel electrophoresis has been used to identify isozymes of each enzyme. The superoxide dismutase and catalase activities per milligram wet weight of calf trabecular meshwork, 0.184 and 0.884 U/mg wet wt, respec...