نتایج جستجو برای: suppressive effect

تعداد نتایج: 1650998  

Journal: :Circulation 1981
C Kawai T Konishi E Matsuyama H Okazaki

Diltiazem, verapamil and nifedipine suppress sinoatrial (SA) nodal function in the excised rabbit heart. Clinically, however, their suppressive effect on the SA node is modified considerably by the reflex increase in sympathetic tone as a result of the fall in blood pressure caused by the vasodilating action of the calcium antagonists. Diltiazem, verapamil and nifedipine suppress atrioventricul...

Journal: :Nature Immunology 2015

Journal: :Journal of Experimental Medicine 2005

Journal: :The Journal of antibiotics 2004
Motoi Ueno Satoko Furukawa Fumie Abe Michiko Ushioda Kiyotaka Fujine Shigeru Johki Hidetaka Hatori Hirotsugu Ueda

The antibiotic thiazole compound siomycin, which we have found from the culture broth of Actinomycetes (strain No.806097) in search of antibody production inhibitor, showed the in vitro immunosuppressive property against B-cells stimulated with T-cell independent antigen DNP-LPS (dinitrophenyl-lipopolysaccharide) while it also showed inhibitory effect against T-cell proliferation. Its inhibitor...

Journal: :Gut 1979
G P Young F J Dudley M B Van Der Weyden

The effect of alcoholic patient sera on in vitro lymphocyte transformation was studied using mitogen-induced uptake of (3)H-thymidine to measure blastogenesis. With pokeweed mitogen as the stimulus, transformation of normal lymphocytes in sera of alcoholics with either normal or fatty livers was not significantly different from that obtained in pooled human serum (PHS). However, in sera of pati...

Journal: :The Journal of Experimental Medicine 1993
C Watts A Lanzavecchia

Immunoglobulins drive efficient antigen capture by antigen presenting cells for processing and presentation on class II MHC-molecules. High affinity antibody/antigen interactions are stable at endosomal/lysosomal pH thus altering the substrate for antigen processing. We show that this can result in strong suppression of presentation of some T cell epitopes. This effect was observed when the ant...

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