The case on contact shots from firearms with a flash suppressor is rare. When a rifle fitted with a flash suppressor is fired, the emerging soot-laden gas in the barrel escapes from the slits of the flash suppressor. If the shot is contact or near contact, the flash suppressor will produce a characteristic "flower-like" pattern of seared, blackened zones around the entrance. This paper presents...

Carcinogenesis is a multistep process attributable to both gain-of-function mutations in oncogenes and loss-of-function mutations in tumor suppressor genes. Currently, most molecular targeted therapies are inhibitors of oncogenes, because inactivated tumor suppressor genes have proven harder to "drug." Nevertheless, in cancers, tumor suppressor genes undergo alteration more frequently than do o...

in this archival analysis of genetic & protein alterations in the p53 tumor suppressor gene, we used immunohistochemical methods for detection of these alterations. the tumor series includes: 61 paraffin embedded esophageal squamous cell carcinoma from a high incidence (ethnic) & a non-high incidence regions in iran.

Background Beta cell dysfunction and death are critical steps in the development of both type 1 2 diabetes (T1D T2D), but underlying mechanisms incompletely understood. Activation essential tumor suppressor transcription factor P53 was linked to beta vitro has been reported several mouse models cells humans with T2D. Therefore, we investigated specific role dysfunction, vivo.

To investigate the effect and mechanism of trichostatin A on bleomycin induced pulmonary fibrosis in mice compared with dexamethasone pirfenidone is objective study. C57 black 6 were instilled intranasal to establish model. They divided into five groups: Control group, model group group. Hematoxylin eosin staining Masson’s was conducted; expression related proteins each observed by immunohistoc...

Background: Breast cancer is one of the cancers with highest incidence in women. Invasive breast carcinoma found most and infiltrates tissues. LC3B a marker autophagy an important protein involved formation autophagosomes. The acts as tumor suppressor. Therefore, lack LC3 expression has been reported to be associated survival high mortality rates TNBC. Objective: To analyze correlation histopat...

Recessive lethal amber suppressor mutations have been isolated in a diploid strain of Saccharomyces cerevisiae. Diploids carrying these suppressors upon sporulation yield asci with only two live spores, both lacking the suppressor. At least two classes of recessive lethal suppressors exist. Aneuploid strains carrying one wild type and one suppressor locus have been isolated and used in mapping ...

Thymus-derived suppressor cells (Ts)1 regulate humoral (1, 2), cell-mediated (3, 4), or proliferative (5) responses, and the characterization of these suppressor systems reveals that there are probably several distinct types of Ts. This has been further complicated by the demonstration in certain systems that one Ts or another immune cell may help induction of other phenotypically distinct Ts (...

The NS3 protein of rice hoja blanca virus represents a viral suppressor of RNA interference (RNAi) that sequesters small interfering (si)RNAs in vitro. To determine whether this siRNA binding property is the critical determinant for the suppressor activity of NS3, NS3 was altered by alanine point mutations and the resulting mutant proteins were tested for both siRNA binding ability and RNAi sup...

An amber suppressor tRNA was prepared in vitro by runoff transcription with T7 RNA polymerase. Both full-length tRNA and truncated tRNA lacking the 3' terminal pCpA from the acceptor stem could be synthesized from the same DNA template. Truncated runoff suppressor tRNA could be enzymatically ligated to phenylalanyl-pCpA to generate aminoacylated full-length suppressor tRNA (Phe-tRNA(CUA)). Phe-...